Registration Dossier
Registration Dossier
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EC number: 211-112-6 | CAS number: 629-82-3
Endpoint summary
Administrative data
Description of key information
The aqua tox data indicate that the toxicity in all tests is above the water solublity of the test item in the respective media. Therefore, no hazards are identified.
Additional information
For each of three trophic levels, one reliable and relevant acute toxicity study is available.
The acute toxicity to fish was determined to be LC50 = 3200 mg/l.
The acute toxicity to Daphnia was determined to be EC50 >100 mg/L.
The acute toxicity to algae was determined to be EC50 (growth rate) = 26.16 mg/L, with a NOEC of 12.5 mg/L.
The acute toxicity to Lemna was determined to be NOEC: 0.942 mg/L , the range of the functional water (media) solubility.
One reliable and relevant chronic toxicity study is available. In a Daphnia reproduction test a NOEC of 12.5 mg/L was determined.
Verification test with Lemna:
In order to overcome potential shortcomings with the analytical monitoring of the test concentrations, it was decided to repeat the algae test OECD 201 with a special focus on recovery rates of the test item in the exposure vessels to verify the previous finding in the acute tests.
In sum 6 different pretest were performed in order to verify the intended exposure concentrations in the range of close to 2 µg/L which corresponds to the functional water solubility in the algae media.
Despite of all reasonable efforts, it was not possible to keep the intended concentration in the exposure vessels under static conditions over the exposure period of 72 hours.
However, predict effects on plant organisms, it seemed more promising to switch to a semi-static testing regime (OECD 221) with Lemna (Lemna gibba) with a daily water exchange of the test medium and a close analytical monitoring of the intended test concentration.
A nominal concentration of 6 µg/L turned out to be a realistic concentration to reach a saturated media concentration of 0.942 µg/L (mean measured). With a NOEC of 0.942 µg/L and an EC10, EC50 > 0.942 µg/L with regard to growth inhibition (frond number and dry weight) as well as to yield inhibition, not effects were observed for Lemna within the range of media solubility.
Conclusion:
The water solubility of the test item in test media is very low. In Lemna media it is in the range of 0.942 µg/L. Based on the Leman test result it can be concluded that in the range of the water solubility, the test item is not toxic to water organisms and therefore is considered to confirm the previous results in algae, daphnia and fish: no toxicity within the range of water solubility.
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