1,1'-(4-chlorobutylidene)bis[4-fluorobenzene]

Endpoint summary

Description of key information

Short-term toxicity to aquatic invertebrates

Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the short term toxicity on aquatic invertebrate predicted for 1,1'-(4-Chlorobutylidene)bis(4-fluorobenzene) (CAS: 3312 -04-7). Effect concentration i.e EC50 value estimated to be 124.54 mg/l for Daphnia magna for 48 hrs duration. It can be concluded that the 1,1'-(4-Chlorobutylidene)bis(4-fluorobenzene) (CAS: 3312-04-7) likely to be not toxic to aquatic invertebrates, hence it can be considered to be “not classified” as per the CLP classification criteria for aquatic environment.

Toxicity to aquatic algae and cyanobacteria

Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the toxicity on algae was predicted 1,1'-(4-Chlorobutylidene)bis(4-fluorobenzene) (CAS: 3312-04-7). Effect concentration i.e EC50 value was estimated to be 115.98 mg/l for Scenedesmus sp. for 72 hrs duration. It was concluded that the 1,1'-(4-Chlorobutylidene)bis(4-fluorobenzene) (CAS: 3312-04-7) was likely to be not toxic to aquatic algae, hence it can be considered to be “not Classified” as per the CLP classification criteria for aquatic environment.

Additional information

Short-term toxicity to aquatic invertebrates

Following two studies for the target and read across chemical includes predicted data from OECD QSAR toolbox and experimental data from peer reviewed journal to conclude the aquatic invertebrate toxicity for 1,1'-(4-Chlorobutylidene)bis(4-fluorobenzene) (CAS: 3312 -04-7) is summarized as follows:

Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the short term toxicity on aquatic invertebrate predicted for 1,1'-(4-Chlorobutylidene)bis(4-fluorobenzene) (CAS: 3312 -04-7). Effect concentration i.e EC50 value estimated to be 124.54 mg/l for Daphnia magna for 48 hrs duration. It can be concluded that the 1,1'-(4-Chlorobutylidene)bis(4-fluorobenzene) (CAS: 3312-04-7) likely to be not toxic to aquatic invertebrates, hence it can be considered to be “not classified” as per the CLP classification criteria for aquatic environment.

The above predicted study is supported by the experimental study of read across chemical 1-chlorobutane (CAS: 109 -69 -3) from water research 1989. suggests that The Effective concentration EC50 to 50% of 5 Daphnia magna 48 h is 3020 mg/l. In the case of defined concentrations of a substance, a specific percentage 50% of daphnids was incapable of swimming at the end of the test period. It can be concluded from the value that the 1-chlorobutane is not toxic to the aquatic environment.

Thus based on the effect concentrations which is in the range 124.54 mg/l to 3020 mg/l give the conclusion that test substance 1,1'-(4-Chlorobutylidene)bis(4-fluorobenzene) (CAS: 3312-04-7) was likely to be not toxic to aquatic invertebrate at environmentally relevant concentrations and can be considered to be“not classified”as per the CLP classification criteria.

Toxicity to aquatic algae and cyanobacteria

Following three studies of target chemical and read across chemical includes predicted data and experimental data to conclude the aquatic algae and cyanobacteria toxicity of 1,1'-(4-Chlorobutylidene)bis(4-fluorobenzene) (CAS: 3312-04-7) are summarized below:

Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the toxicity on algae was predicted 1,1'-(4-Chlorobutylidene)bis(4-fluorobenzene) (CAS: 3312-04-7). Effect concentration i.e EC50 value was estimated to be 115.98 mg/l for Scenedesmus sp. for 72 hrs duration. It was concluded that the 1,1'-(4-Chlorobutylidene)bis(4-fluorobenzene) (CAS: 3312-04-7) was likely to be not toxic to aquatic algae, hence it can be considered to be “not Classified” as per the CLP classification criteria for aquatic environment.

The above predicted data is supported by the experimental data of read across 2-chloropropane (CAS: 75-29-6) from chemosphere 1994, indicates that The Effective concentration to 50% of Scenedesmus subspicatus is 870 g/mol. Considering Population changes effects, It can be concluded that the 2-chloropropane is not toxic to aquatic algae.

Similar experimental study available for another read across Bromocyclen (CAS: 1715-40-8), from Munch.Beitr.Abwasser-, Fisch.- Flussbiol. 1997 suggests that The Effective concentration EC50 to 50% of Scenedesmus Subspicatus (Green algae) at 72 his >100 mg/l. IT can be concluded from the value that the Bromocyclen is not toxic to the aquatic environment.

Thus based on the effect concentrations which is in the range > 100 mg/l to 870 mg/Lgive the conclusion that test substance 1,1'-(4-Chlorobutylidene)bis(4-fluorobenzene) (CAS: 3312-04-7) was likely to be not toxic to aquatic algae at environmentally relevant concentrations and can be considered to be“not classified”as per the CLP classification criteria.