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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
03.11.1980-
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report date:
1981

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
Method: other: regulatory procedure
GLP compliance:
yes
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Alcohols, C9-11-branched and linear
EC Number:
288-284-4
EC Name:
Alcohols, C9-11-branched and linear
Cas Number:
85711-26-8
Molecular formula:
C9H20O, C10H22O and C11H24O
IUPAC Name:
Alcohols, C9-11-branched and linear
Test material form:
other: moderately viscous liquid

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Charles River, Portage, Michigan, US
- Age at study initiation: Not reported.
- Weight at study initiation: males 213.9 + or - 8.1g; females 170 + or -  10.4 g (fasted weights for treated animals)
- Fasting period before study: overnight
- Housing: individual polycarbonate/wire mesh cages
- Diet: ad libitum, except during exposure
- Water: yes, ad libitum
- Acclimation period: 14 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): average 23.3
- Humidity (%): average 54.9
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
MAXIMUM DOSE VOLUME APPLIED: 5ml/kg

Doses:
5 ml/kg
No. of animals per sex per dose:
5M, 5F
Control animals:
yes
Remarks:
5M+5F receiving 5 ml/kg distilled water.
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed:  All rats were necropsied at the end of the  observation period.
- Other examinations performed: Clinical signs were recorded hourly for 6 hours after  dosing then at 24 hours and twice daily throughout the 14-day observation  period.  Body weights were recorded the day before dosing and at 7 and 14 days. A fasted body weight was taken prior to dosing and used for  calculation of the dosage.

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 mL/kg bw
Based on:
test mat.
Remarks on result:
other: equivalent to 4000 mg/kg bw based on the lower value of density range, 0.8 g/cm3)
Mortality:
There were no mortalities in either test or control animals.
Clinical signs:
other: All treated animals had diarrhoea at 0.5 -1.5 hours after  dosing, while 4/5 males and all females had polyuria by 24 hours after  dosing. Among control animals one female had polyuria. All animals  appeared normal by 54 hours post-dosing. The only other 
Gross pathology:
There was no observable pathology in either test or  control animals.
Other findings:
POTENTIAL TARGET ORGANS: No conclusions.
SEX-SPECIFIC DIFFERENCES: None

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The acute oral toxicity study for Alcohols, C9-11 branched and linear, conducted according to a protocol similar to the now-deleted OECD Test Guideline 401 and in compliance with GLP, reports an LD50 value of >4000 mg/kg bw.