Registration Dossier
Registration Dossier
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EC number: 288-284-4 | CAS number: 85711-26-8
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP
Data source
Reference
- Reference Type:
- publication
- Title:
- Percutaneous absorption of aliphatic compounds.
- Author:
- Iwata Y, Moriya Y, Kobayashi T
- Year:
- 1 987
- Bibliographic source:
- Cosmet. Toiletries 102(2): 53-68.
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- n-decyl alcohol
- IUPAC Name:
- n-decyl alcohol
- Reference substance name:
- Decan-1-ol
- EC Number:
- 203-956-9
- EC Name:
- Decan-1-ol
- Cas Number:
- 112-30-1
- Molecular formula:
- C10H21OH
- IUPAC Name:
- decan-1-ol
- Test material form:
- liquid
Constituent 1
Constituent 2
- Radiolabelling:
- yes
Test animals
- Species:
- mouse
- Strain:
- other: HR/De
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- also tested in three solvent vehicles: TEC, castor oil and squalane.
- Duration of exposure:
- 24 hours
- Doses:
- Up to 100% concentration in three vehicles and undiluted
- No. of animals per group:
- 3
- Control animals:
- no
Results and discussion
Percutaneous absorption
- Key result
- Dose:
- 100%
- Parameter:
- percentage
- Absorption:
- ca. 7 %
- Remarks on result:
- other: 24 hours
Any other information on results incl. tables
The percentage absorbance of dose 14C-decyl alcohol (decanol) = ca 7 %. At least 65% of the absorbed dose is excreted as carbon dioxide in the expired air.
When tested diluted in solvent vehicles, the degree of absorption was influenced by the concentration and the type of solvent that was used.
For n-decyl alcohol in squalane, the fraction of the dose that was absorbed varied between approximately 5% of the applied dose at 50% concentration to approximately 27% of the applied dose at 0.5% concentration.
For n-decyl alcohol in castor oil, approximately 5% of the applied dose was absorbed at all tested concentrations (<0.1% - 50%).
For n-decyl alcohol in TEC (triethyl citrate), approx 5 -7% of the applied dose was absorbed at concentations of 0.5 -50%.
Applicant's summary and conclusion
- Conclusions:
- Of a dose of undiluted 1-14C-decyl alcohol applied to the skin of nude mice for 24 hours, 7% was absorbed.
- Executive summary:
Of a dose of undiluted 1-14C-decyl alcohol applied to the skin of nude mice for 24 hours, 7% was absorbed.
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