Registration Dossier
Registration Dossier
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EC number: 201-854-9 | CAS number: 88-73-3
Toxicity to reproduction
Administrative data
- Endpoint:
- toxicity to reproduction
- Remarks:
- other: T41-04:
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study
Data source
Referenceopen allclose all
- Title:
- No information
- Author:
- Horstman, M.G. et al.: The Toxicologist 11, 87 (1991) (abstr.)
- Title:
- No information
- Author:
- NTP, Technical Report Series No. 33, NIH Publication 93-3382, July/1993
Materials and methods
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1-chloro-2-nitrobenzene
- EC Number:
- 201-854-9
- EC Name:
- 1-chloro-2-nitrobenzene
- Cas Number:
- 88-73-3
- Molecular formula:
- C6H4ClNO2
- IUPAC Name:
- 1-chloro-2-nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): 1-chlor-2-nitrobenzene
- Analytical purity: 99 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: F344/N
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Duration of treatment / exposure:
- Exposure period: 13 w
- Frequency of treatment:
- 6 h/d, 5 d/w
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 4.5, 9 or 18 ppm (approx. 0, 28.8, 57.6, 115.2 mg/m3)
Basis:
- No. of animals per sex per dose:
- 10
- Control animals:
- yes, concurrent no treatment
Results and discussion
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
females: no effects observed
males, 18 ppm: decreases in cauda epididymis weights (6.8%),
and in the spermatid count and spermatid heads/testis (ca.
13%)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
