Registration Dossier
Registration Dossier
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EC number: 201-854-9 | CAS number: 88-73-3
Carcinogenicity
Administrative data
Description of key information
1 -chloro-2 -nitrobenzene has a carcinogenic potential.
Key value for chemical safety assessment
Justification for classification or non-classification
Classification:
DSD: Category 3, Xn, R40 Limited evidence of a carcinogenic effect
EU-GHS: Category 2 carcinogen
Additional information
In two studies the cancer potential of 1 -chloro-2 -nitrobenzene was investigated in rats and mice (Weisburger et al., 1978 and Matsumoto et al., 2006).
Multiple tumours at the low dose were observed in rats (no dose-response) and liver tumours in mice (Weisburger et al., 1978). A pituitary adenoma along with either a stomach papilloma, adrenal tumour, thyroid adenocarcinoma, lymphosarcoma, choliangosarcoma of the liver or subcutaneous fibroma was observed (incidences: low dose level:7/22, high dose level:1/19, simultaneous control: 1/22, pooled control: 14/111).
In the second study hepatic tumours in rats and mice were reported (Matsumoto et al., 2006).
There is evidence that 1 -chloro-2 -nitrobenzene has a carcinogenic potential.
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