Registration Dossier
Registration Dossier
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EC number: 201-854-9 | CAS number: 88-73-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1992
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Adopted according to OECD SIDS, peer reviewed data
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Reference Type:
- secondary source
- Title:
- 1-Chloro-2-nitrobenzene CAS: 88-73-3, SIDS Initial Assessment Report
- Author:
- OECD
- Year:
- 2 001
- Bibliographic source:
- UNEP publications
Materials and methods
- Principles of method if other than guideline:
- Method: other: 10 male rats/conc., head-only exposure, 6 conc., heated vapour was diluted with humidified and O2-enriched air and thus converted to a mixture of vapour and liquid aerosol, post exposure observation time: 14 d
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 1-chloro-2-nitrobenzene
- EC Number:
- 201-854-9
- EC Name:
- 1-chloro-2-nitrobenzene
- Cas Number:
- 88-73-3
- Molecular formula:
- C6H4ClNO2
- IUPAC Name:
- 1-chloro-2-nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): 1-chloro-2-nitrobenzene
- Analytical purity: 99.8%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CD
- Sex:
- male
Administration / exposure
- Route of administration:
- other: inhalation: mixture of vapour and liquid aerosol
- Duration of exposure:
- 4 h
- No. of animals per sex per dose:
- 10
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- ca. 3 200 mg/m³ air
- Exp. duration:
- 4 h
- Gross pathology:
- not reported
Any other information on results incl. tables
value: LD50: 495 ppm
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
