Registration Dossier
Registration Dossier
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EC number: 201-854-9 | CAS number: 88-73-3
Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Test procedure according to national standards. Adopted according to OECD SIDS. The original source is available and has been reviewed.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Reference Type:
- secondary source
- Title:
- 1-Chloro-2-nitrobenzene CAS: 88-73-3, SIDS Initial Assessment Report
- Author:
- OECD
- Year:
- 2 001
- Bibliographic source:
- UNEP publications
Materials and methods
- Principles of method if other than guideline:
- proposed preliminary testing method by the Federal Environmental Agency of Germany (UBA): "Prolonged toxicity test on Daphnia magna (determination of NOEC for reproduction rate, mortality and time of the first appearance of offspring; 21 d)", (1984)
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-chloro-2-nitrobenzene
- EC Number:
- 201-854-9
- EC Name:
- 1-chloro-2-nitrobenzene
- Cas Number:
- 88-73-3
- Molecular formula:
- C6H4ClNO2
- IUPAC Name:
- 1-chloro-2-nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): 1-Chlor-2-nitrobenzol
- Analytical purity: no data
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Age of test animals at the start of the experiment: < 24 h
- Feeding during test
- Food type: TetraMin and activated sludge
- Frequency: daily
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
Test conditions
- Test temperature:
- 25 ± 1 °C
- pH:
- 8.0 ± 0.3
- Dissolved oxygen:
- - prior to test the water was saturated with air
- at the end of the test (21 d) the DOC was around 73% - Nominal and measured concentrations:
- nominal concentrations: 0.125 - 16 mg/L
- Details on test conditions:
- - 5 replicates
- 5 animals/250 mL medium (=> 25 animals per concentration)
- photoperiod: 9 h artificial light, 15 h darkness
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 3 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks on result:
- other: based on a recovering rate of 75%
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
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