Registration Dossier
Registration Dossier
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EC number: 431-460-4 | CAS number: 10061-02-6
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Siehe Bemerkungen.
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- -
- EC Number:
- 431-460-4
- EC Name:
- -
- Cas Number:
- 10061-02-6
- Molecular formula:
- C3H4Cl2
- IUPAC Name:
- (1E)-1,3-dichloroprop-1-ene
- Test material form:
- liquid
- Details on test material:
- Batch no: TR 88001
Also know as ST088/098
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: sat TA 98, 100, 1535, 1537, 1538, esc WP2 uvrA; pKM101
- Metabolic activation system:
- Aroclor 1254 induced rat liver S9-homogenate.
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 39.1 ... 2500 µg/plate
Concentration range in the main test (without metabolic activation): 39.1 ... 2500 µg/plate - Vehicle / solvent:
- Solvent: Acetone
- Details on test system and experimental conditions:
- Concentration of the test substance resulting in precipitation: 2500 µg/plate
Results and discussion
Test resultsopen allclose all
- Species / strain:
- other: as specified above
- Metabolic activation:
- with
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (>= 1250 µg/plate)
- Species / strain:
- other: as specified above
- Metabolic activation:
- without
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (>= 625 µg/plate)
- Species / strain:
- other: as specified above
- Metabolic activation:
- without
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (>= 1250 µg/plate)
- Remarks on result:
- other: other: preliminary test
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
toxicity: with S-9 mix from 1250 μg/plate; without S-9 mix from 625 μg/plate upwards.
precipitations: with and without S-9 mix at the highest tested dose of 2500 μg/plate.
characterisation of the positive finding: positive with and without S-9 mix in the dose range 312.5 to 1250 μg/plate; reproducible and dose-dependent effects.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results:
positive with metabolic activation
positive without metabolic activation
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