Registration Dossier
Registration Dossier
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EC number: 431-460-4 | CAS number: 10061-02-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 84/449/EWG, B.5
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 431-460-4
- EC Name:
- -
- Cas Number:
- 10061-02-6
- Molecular formula:
- C3H4Cl2
- IUPAC Name:
- (1E)-1,3-dichloroprop-1-ene
- Test material form:
- liquid
- Details on test material:
- Batch no: TR 88001
Also know as ST088/098
Constituent 1
Test animals / tissue source
- Species:
- other: rbt, New Zealand White (SPF)
Test system
- Amount / concentration applied:
- .1 ML
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- mean
- Score:
- 2.1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- other: Max. duration of any effect : 14 d; Max. value at end of observation period: 0
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Score:
- 1.2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 d
- Remarks on result:
- other: Max. duration of any effect : 7 d; Max. value at end of observation period: 0
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Score:
- 0.7
- Max. score:
- 1
- Reversibility:
- fully reversible within: 7 d
- Remarks on result:
- other: Max. duration of any effect : 7 d; Max. value at end of observation period: 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Score:
- 0.1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 2 d
- Remarks on result:
- other: Max. duration of any effect : 48 h; Max. value at end of observation period: 0
- Irritant / corrosive response data:
- Reversibility of any observed effect: Changes fully reversible within 14 days
- Other effects:
- Instillation of the test substance resulted in severe
initial pain responses. Conjunctival irritation was apparent
in all rabbits one hour after ocular instillation of the
test substance. Minor corneal opacities developed in five
rabbits and there were iridial responses in three of the
same animals within 24 hours of treatment.
Maximum irritation responses, observed between 4 and
24 hours after treatment, were a beefy-red appearance of the
conjunctivae, chemosis obscuring up to one half of the eye,
diffuse opacity of the cornea and congestion of the iris.
Resolution of the irritant effects of the test substance was
advanced seven days after treatment and complete one week
later.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
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