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Diss Factsheets
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EC number: 204-606-8 | CAS number: 123-17-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- circa 1949
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted prior to GLP and Test guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 949
- Report date:
- 1949
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Varying volumes of undiluted or diluted test material placed in center of cornea, from 0.001ml and up to 0.5 ml (excess). One eye scored for evidence of injury and corneal damage. Eye scored 24 hours after exposure to test material.
- GLP compliance:
- no
- Remarks:
- Study conducted prior to GLP
Test material
- Reference substance name:
- 2,6,8-trimethylnonan-4-ol
- EC Number:
- 204-606-8
- EC Name:
- 2,6,8-trimethylnonan-4-ol
- Cas Number:
- 123-17-1
- Molecular formula:
- C12H26O
- IUPAC Name:
- 2,6,8-trimethylnonan-4-ol
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): Trimethyl Nonanol, undiluted
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or tissues and environmental conditions:
- No additional information available.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- Report does not state amount administered. However, previous publications by the laboratory states 0.5 ml was applied to the eye (Smyth and Carpenter, 1944).
Reference
Smyth Jr., H.F. and Carpenter, C.P. (1944). The Place of the Range Finding Test in the Industrial Toxicology Laboratory. J. Industrial Hygiene and Toxicology. 26: 269-273. - Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- Animals were observed at 24 hours.
- Number of animals or in vitro replicates:
- Not stated in report. However, previous publications by the laboratory states one albino rabbit was used (Smyth and Carpenter, 1944).
Reference
Smyth Jr., H.F. and Carpenter, C.P. (1944). The Place of the Range Finding Test in the Industrial Toxicology Laboratory. J. Industrial Hygiene and Toxicology. 26: 269-273. - Details on study design:
- Undiluted test material was placed on the center of the cornea of an albino rabbit which had been shown to have uninjured eyes, and twenty four hours later observed the eye for gross evidence of injury and for corneal necrosis revealed by fluorescein stain.
Results and discussion
In vivo
Results
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- The rabbit eye was essentially unharmed by the instillation of an excess of the undiluted chemical.
- Other effects:
- No additional information available.
Any other information on results incl. tables
No additional information available.
Applicant's summary and conclusion
- Conclusions:
- Based on the results of the study, the test material is virtually harmless to the rabbit eye.
- Executive summary:
The eye irritation potential of trimethylnonanol was investigated. The rabbit eye was essentially unharmed by the instillation of an excess of undiluted chemical.
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