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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
circa 1949
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study was conducted prior to GLP and Test guidelines.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1949
Report date:
1949

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Varying volumes of undiluted or diluted test material placed in center of cornea, from 0.001ml and up to 0.5 ml (excess). One eye scored for evidence of injury and corneal damage. Eye scored 24 hours after exposure to test material.
GLP compliance:
no
Remarks:
Study conducted prior to GLP

Test material

Constituent 1
Chemical structure
Reference substance name:
2,6,8-trimethylnonan-4-ol
EC Number:
204-606-8
EC Name:
2,6,8-trimethylnonan-4-ol
Cas Number:
123-17-1
Molecular formula:
C12H26O
IUPAC Name:
2,6,8-trimethylnonan-4-ol
Test material form:
not specified
Details on test material:
- Name of test material (as cited in study report): Trimethyl Nonanol, undiluted

Test animals / tissue source

Species:
rabbit
Strain:
other: albino
Details on test animals or tissues and environmental conditions:
No additional information available.

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
Report does not state amount administered. However, previous publications by the laboratory states 0.5 ml was applied to the eye (Smyth and Carpenter, 1944).

Reference
Smyth Jr., H.F. and Carpenter, C.P. (1944). The Place of the Range Finding Test in the Industrial Toxicology Laboratory. J. Industrial Hygiene and Toxicology. 26: 269-273.
Duration of treatment / exposure:
24 hours
Observation period (in vivo):
Animals were observed at 24 hours.
Number of animals or in vitro replicates:
Not stated in report. However, previous publications by the laboratory states one albino rabbit was used (Smyth and Carpenter, 1944).

Reference
Smyth Jr., H.F. and Carpenter, C.P. (1944). The Place of the Range Finding Test in the Industrial Toxicology Laboratory. J. Industrial Hygiene and Toxicology. 26: 269-273.
Details on study design:
Undiluted test material was placed on the center of the cornea of an albino rabbit which had been shown to have uninjured eyes, and twenty four hours later observed the eye for gross evidence of injury and for corneal necrosis revealed by fluorescein stain.

Results and discussion

In vivo

Results
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
The rabbit eye was essentially unharmed by the instillation of an excess of the undiluted chemical.
Other effects:
No additional information available.

Any other information on results incl. tables

No additional information available.

Applicant's summary and conclusion

Conclusions:
Based on the results of the study, the test material is virtually harmless to the rabbit eye.
Executive summary:

The eye irritation potential of trimethylnonanol was investigated. The rabbit eye was essentially unharmed by the instillation of an excess of undiluted chemical.