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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
circa 1949
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: This study was conducted prior to GLP and test guidelines and very limited information is available for interpretation of results

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1949
Report date:
1949

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Test material was applied to the skin of the rabbit and observed twenty four hours later.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,6,8-trimethylnonan-4-ol
EC Number:
204-606-8
EC Name:
2,6,8-trimethylnonan-4-ol
Cas Number:
123-17-1
Molecular formula:
C12H26O
IUPAC Name:
2,6,8-trimethylnonan-4-ol
Details on test material:
- Name of test material (as cited in study report): Trimethyl Nonanol

Test animals

Species:
rabbit
Strain:
other: albino

Test system

Type of coverage:
not specified
Preparation of test site:
other: clipped
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Duration of treatment / exposure:
Not stated in report. According to an earlier publication by these authors, test material was applied to the skin for 24 hours (Smyth and Carpenter, 1944).

Reference
Smyth Jr., H.F. and Carpenter, C.P. (1944). The Place of the Range Finding Test in the Industrial Toxicology Laboratory. j. Industrial Hygiene and Toxicology. 26:269-273.
Observation period:
Not stated in report. Twenty four hours post application according to Smyth and Carpenter, 1944.
Number of animals:
Not stated in report. One animal was used according to Smyth and Carpenter, 1944.

Results and discussion

In vivo

Results
Remarks on result:
other: No reaction more severe than capillary injection resulted from the application of the undiluted compound to the skin of the rabbit belly in the vesicant test.
Other effects:
No reaction more severe than capillary injection resulted from the application of the undiluted compound to the skin of the rabbit belly in the vesicant test.

Any other information on results incl. tables

No additional information available.

Applicant's summary and conclusion

Conclusions:
No reaction more severe than capillary injection was observed following administration of 0.01 ml to the skin of a rabbit. This amount is less than current guidelines call for.
Executive summary:

The skin irritation potential of trimethylnonanol was examined. No reaction more severe than capillary injection was observed following administration of 0.01 ml to the skin of a rabbit. This amount is less than current guidelines call for.