Registration Dossier
Registration Dossier
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EC number: 202-431-1 | CAS number: 95-55-6
Toxicity to reproduction
Administrative data
- Endpoint:
- multi-generation reproductive toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary source SCCS opinion on o-aminophenol 2010
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Multigeneration reproduction and carcinogenicity studies in Sprague-Dawley rats exposed topically to oxidative hair-colouring formulations containing p-phenylenediamine and other aromatic amines
- Author:
- Burnett C.M. et al.
- Year:
- 1 988
- Bibliographic source:
- SCCS opinion on o-aminophenol 2010
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-aminophenol
- EC Number:
- 202-431-1
- EC Name:
- 2-aminophenol
- Cas Number:
- 95-55-6
- Molecular formula:
- C6H7NO
- IUPAC Name:
- 2-aminophenol
- Details on test material:
- hair dye formulation containing 0.3% o-aminophenol (formula 7405) was mixed with an equal volume of 6% H2O2 (final concentration 0.15% o-aminophenol)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Charles River
- Sex:
- male/female
Administration / exposure
- Route of administration:
- dermal
- Details on exposure:
- A hair dye formulation containing 0.3% o-aminophenol (formula 7405) was mixed with an equal volume of 6% H2O2 (final concentration 0.15% o-aminophenol) and applied twice weekly through growth, mating (day 100), gestation and lactation to the weaning litters of the respective generation of Charles River rats. The dosage was 0.5 ml per animal. The group size was 40 males and 40 females. The controls were only clipped and not further treated.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.15 %
Basis:
nominal conc.
- No. of animals per sex per dose:
- 40
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Dose descriptor:
- NOAEL
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified Generation not specified (migrated information)
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
