Registration Dossier
Registration Dossier
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EC number: 202-431-1 | CAS number: 95-55-6
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
No skin sensitizing reaction was observed in a study with guinea-pigs. However, a study with two different protocols showed no sensitization with one protocol and a 20% positive response with the other protocol. These studies are not according to modern standards and not in compliance with GLP. In a compilation of LLNA data, 2-aminophenol was found to be a sensitiser of high potency. It was also identified as a skin sensitizer in the direct peptide binding assay, and a direct adduct could be identified.
Justification for classification or non-classification
An EC3 of 0.4 observed in a non-described LLNA has been published. Although no details on this result is available, it is plausible since the substance is reactive in all in-vitro assays for skin sensitization. According to the criteria laid out in the CLP-directive, the EC3 value of less than 2 identifies 2 -aminophenol as a skin senstizer of high potency (GHS Cat 1A).
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