Registration Dossier
Registration Dossier
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EC number: 202-642-9 | CAS number: 98-15-7
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-chloro-α,α,α-trifluorotoluene
- EC Number:
- 202-642-9
- EC Name:
- 3-chloro-α,α,α-trifluorotoluene
- Cas Number:
- 98-15-7
- Molecular formula:
- C7H4ClF3
- IUPAC Name:
- 1-chloro-3-(trifluoromethyl)benzene
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: HOECHST AG, Kastengrund, SPF-Zucht
- Strain: Hoe: WISKf (SPF71)
- Age at study initiation: 8 - 10 weeks
- Weight at study initiation: males: 189 g - 196 g (average 192 g); females: 186 g - 193 g (average 189 g)
- Housing: 5 animals per makrolon cage
- Diet: Altromin 1324 rat diet, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2°C
- Humidity (%): 50 +/- 20%
- Photoperiod: 12 hrs dark / 12 hrs light
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- Gas chromatography with external standard
- Duration of exposure:
- 4 h
- Concentrations:
- 23,6 mg/L
- No. of animals per sex per dose:
- 5 animals per sex per dose in the treatment groups
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: all animals 14 days
exposure 21 days
- Frequency of observations: exact observation during inhalation period
- Frequency of weighing: before exposure, day 7 and 14 post exposure
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 23.6 mg/m³ air (analytical)
- Based on:
- act. ingr.
- Exp. duration:
- 4 h
- Mortality:
- No animals died during exposure or post exposure period
- Clinical signs:
- other: Besides to nonspecific symptoms, the animals showed impairments of movement and breathing. In addition, trembling, decreased control reflex, drowsiness and anesthesia were observed.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the results of this study the 4h LC50 of 3-Chlorobenzotrichloride is greater than 23.6 mg/L.
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