Registration Dossier
Registration Dossier
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EC number: 279-301-6 | CAS number: 79817-70-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- Referenced as Method B4 in Commision DIrective 84/449/EEC
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1',2'-dihydro-6'-hydroxy-3,4'-dimethyl-2'-oxo-1,3'-bipyridinium chloride
- EC Number:
- 279-301-6
- EC Name:
- 1',2'-dihydro-6'-hydroxy-3,4'-dimethyl-2'-oxo-1,3'-bipyridinium chloride
- Cas Number:
- 79817-70-2
- Molecular formula:
- C12H13N2O2.Cl
- IUPAC Name:
- 6'-hydroxy-3,4'-dimethyl-2'-oxo-1',2'-dihydro-1,3'-bipyridinium dichloride
- Test material form:
- liquid
- Details on test material:
- Active su
Constituent 1
- Specific details on test material used for the study:
- The test material was a dark brown liquid contained in a opaque plastic jar at room temperature.
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Three rabbits were 12 to 16 weeks old. They were individually housed in suspended metal cages. Free acess to mains drinking water and food was allowed.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- other: gauze patch impregnated with the material and in contact with the animal
- Amount / concentration applied:
- 0.5 ml of test material
- Duration of treatment / exposure:
- 4 hours
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- not specified
- Remarks on result:
- probability of mild irritation
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test material did not produce positive criteria in any rabbit according to the EEC labelling regulations and was classified as NON-IRRITANT to rabbit skin. No symbol and risk phrase are therefore required.
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