Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

The requirements of REACH are to provide an assessment of the toxicokinetic behaviour of the substance to the extent that can be derived from the relevant available information.

Studies in rats exposed by inhalation show that 1-chloro-1,1-difluoroethane is rapidly absorbed by the lungs. Analysis of selected tissues from rats and dogs exposed by inhalation for 13 weeks did not reveal the presence of 1-chloro-1,1-difluoroethane and no significant increase in inorganic fluoride in the urine was observed. This is consistent with a low metabolisation of the substance, as indicated by physiologically based pharmacokinetics of uptake by inhalation in rats.