Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 214-426-1 | CAS number: 1126-79-0
Endpoint summary
Administrative data
Description of key information
The similarity of the acute toxicity of all three trophic levels was apparent in the full suite of available experimental data. The predicted and experimental EC/LC50 values for butyl phenyl ether ranged from 2.1 - 5.77 mg/L across all species and trophic levels. Since the acute invertebrate toxicity of 2.1 mg/L was the lowest toxicity value, this was used to derive the predicted no effect concentration in the aquatic environment for butyl phenyl ether.
Additional information
Butyl phenyl ether acute toxicity to fish was determined in a single fish species, the fathead minnow (Pimephales promelas). Two fathead minnow 96 -hr LC50 values for butyl phenyl ether are available; one 96-hr LC50 was determined with juvenile fish (i.e. 5.77 mg/L), while the other 96-hr LC50 value was determined with larval fathead minnows (i.e. >5.88 mg/L). Additionally, a 7-day LC50 value with larval fathead minnows is available for butyl phenyl ether. Since the 7-day LC50 value was the lowest for butyl phenyl ether, this value of 3.28 mg/L was used as the key value in the chemical safety assessment for fish acute toxicity.
The acute toxicity of butyl phenyl ether was experimentally determined in two species of invertebrates, Daphnia magna and Ceriodaphnia dubia. The 24-hr LC50 for butyl phenyl ether with C. dubia was 3.2 mg/L, and the 24-hr LC50 for butyl phenyl ether with D. magna was 2.1 mg/L. A daphnia acute toxicity QSAR was conducted and the estimated 48-hr LC50 for Daphnia sp. was 3.3 mg/L. Since the experimental LC50 value with D. magna was the lowest value, this value was used as the key value for the assessment of acute invertebrate toxicity.
The 72 h EC50 of butyl phenyl ether was evaluated in one species of green algae, Pseudokirchneriella subcapitata. The EC50 and NOEC values (based on growth rate) for Pseudokirchneriella subcapitata exposed to butyl phenyl ether over a 72-hour static exposure period were 2.84 mg/L and 0.183 mg/L, respectively. The acute toxicity of butyl phenyl ether was also estimated via QSAR. The EC50 for algae via QSAR estimation was 4.4 mg/L, which was in good agreement with the experimental results. Since the experimental results were slightly lower than the QSAR results, and since there was greater certainty associated with the experimental results, the value of 2.84 mg/L was used as the key value for the assessment of acute algae toxicity.
The similarity of the acute toxicity of all three trophic levels was apparent in the full suite of available experimental data. The predicted and experimental EC/LC50 values for butyl phenyl ether ranged from 2.1 - 5.77 mg/L across all species and trophic levels. Since the acute invertebrate toxicity of 2.1 mg/L was the lowest toxicity value, this was used to derive the predicted no effect concentration in the aquatic environment for butyl phenyl ether.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
