N-butyl phenyl ether

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: This was a guideline compliant study that was well documented and in accordance with Good Laboratory Practices.

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Water solubility:

36.6 mg/L

Temp.:

20 °C

pH:

8.44

Details on results:

The average concentrations of the test material between sampling periods of 24 and 48 hrs differed by 1.72%, therefore the test was deemed
satisfactory and additional sampling/analyses of the remaining test vessels was not necessary. These two independent water solubility values
averaged 36.6 ± 0.7 mg/L (mean ± 1 std. dev.). The pH of the two test mixtures was 8.44 and 8.58, whereas the pH of Ultrapure water blanks was 6.90. Because the test material does not possess ionizable functional groups, a pH-dependent water solubility is not expected.

Conclusions:

Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The water solubility value determined for butyl phenyl ether averaged 36.6 ± 0.7 mg/L at 20 °C in Ultrapure water.

Executive summary:

The water solubility of butyl phenyl ether was determined following the OECD Guideline 105: Flask Method. A series of test mixtures containing an excess of test substance (350 mg/L, or 5-fold excess of the estimated water solubility) in ultrapure water were prepared in sealed glass vessels. The mixtures were placed on an orbital shaker within an incubator held at 30 °C (+ 1 °C). After mixing at this temperature for 24 hours, one of the mixtures was removed and placed on a similar orbital shaker inside an incubator held at 20 °C (+ 1 °C). Mixing was continued at both 30 and 20 °C for 24 hours. The mixture from the 20 °C incubation was analyzed for butyl phenyl ether, and a second mixture was transferred from the 30 °C to the 20 °C incubator and all were mixed for an additional 24 hrs. Following mixing, the test vessels were inverted and triplicate 10 μL samples were removed using a Hamilton syringe. The samples were diluted with 50:50 acetonitrile:Ultrapure water and the concentration of butyl phenyl ether was determined by high performance liquid chromatography (HPLC) with a Diode Array Detector (DAD). The water solubility values determined at 20 °C for butyl phenyl ether averaged 36.6 ± 0.7 mg/L (mean ± 1 std. dev., n = 2) in ultrapure water.

Description of key information

The water solubility values determined at 20 °C for butyl phenyl ether averaged 36.6 ± 0.7 mg/L (mean ± 1 std. dev., n = 2) in ultrapure water.

Key value for chemical safety assessment

Water solubility:

36.6 mg/L

at the temperature of:

20 °C

Additional information

The water solubility of butyl phenyl ether was determined following the OECD Guideline 105: Flask Method.The water solubility values determined at 20 °C for butyl phenyl ether averaged 36.6 ± 0.7 mg/L (mean ± 1 std. dev., n = 2) in ultrapure water.