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Registration Dossier
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EC number: 202-057-9 | CAS number: 91-29-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from Authoritive database
Data source
Referenceopen allclose all
- Reference Type:
- other: Authoritive database
- Title:
- Skin irritation for CAS NO: 91-29-2
- Author:
- IFA GESTIS
- Year:
- 2 017
- Bibliographic source:
- GESTIS SUBSTANCE Database (information system in hazardous substance of the Berufsgenossenscheftn).
- Reference Type:
- secondary source
- Title:
- Toxicological evaluations -4-Nitro-4’-aminodiphenylamine-2-sulfonic acid
- Author:
- BG Chemie
- Year:
- 2 000
- Bibliographic source:
- BG Chemie InfoCenter TOXIKOLOGISCHE BEWERTUNGEN; 06/2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- Primary Skin irritation study was performed in 3 female albino rabbits to determine the irritation potential of test chemical 4-nitro-4’-aminodiphenylamine-2-sulfonic acid according to OECD guideline no 404.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-(4-aminoanilino)-5-nitrobenzenesulphonic acid
- EC Number:
- 202-057-9
- EC Name:
- 2-(4-aminoanilino)-5-nitrobenzenesulphonic acid
- Cas Number:
- 91-29-2
- Molecular formula:
- C12H11N3O5S
- IUPAC Name:
- 2-(3-(4-amino-9,10-dihydro-3-sulpho-9,10-dioxoanthracen-4-yl)aminobenzenesulphonyl)vinyl) disodium sulphate
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report): 4-nitro-4’-aminodiphenylamine-2-sulfonic acid (91-29-2)
- Molecular formula: C12H11N3O5S
- Molecular weight : 309.301 g/mol
- Substance type: Organic
- Physical state: Solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 4-nitro-4’-aminodiphenylamine-2-sulfonic acid
- Molecular formula: C12H11N3O5S
- Molecular weight: 309.301 g/mol
- Substance type: Organic
- Physical state: Solid
Test animals
- Species:
- rabbit
- Strain:
- other: HC:NZW
- Details on test animals or test system and environmental conditions:
- - Sex: Female
- Age at study initiation: adult
- Weight at study initiation: 3.2-3.3 kg
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: Mechanically depilated skin of flanks
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 4 hrs
- Observation period:
- 1,24,48 and 72 hrs and day 7
- Number of animals:
- 3 female rabbits
- Details on study design:
- SCORING SYSTEM: Draize method.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- None of the test animals produced skin reactions.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not irritating
- Conclusions:
- The average irritation scores according to the Draize scoring for erythema and oedema were 0.0.
Hence, 4-nitro-4’-aminodiphenylamine-2-sulfonic acid (CAS No:91-29-2) was considered to be not irritating to skin of female albino rabbits - Executive summary:
Primary Skin irritation study was conducted for test chemical4-nitro-4’-aminodiphenylamine-2-sulfonic acid (CAS No:91-29-2) to determine its skin irritating behavior in accordance withOECD guideline No. 404. The animals were subjected to a single 4- hour exposure to 500 mg of the test substance, mixed into a paste with water and applied semi-occlusively to the mechanically depilated skin of the flanks. The findings were scored after 1, 24, 48 and 72 hours as well as 7 days in accordance with the Draize method.
The average irritation scores according to the Draize scoring for erythema and oedema were 0.0.
Hence, 4-nitro-4’-aminodiphenylamine-2-sulfonic acid (CAS No:91-29-2) was considered to be not irritating to skin of female albino rabbits
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