Registration Dossier
Registration Dossier
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EC number: 620-459-6 | CAS number: 130841-23-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1,4-dichloro-2-(1,1,2,3,3,3-hexafluoropropoxy)-5-nitrobenzene
- EC Number:
- 620-459-6
- Cas Number:
- 130841-23-5
- Molecular formula:
- C9H3Cl2F6NO3
- IUPAC Name:
- 1,4-dichloro-2-(1,1,2,3,3,3-hexafluoropropoxy)-5-nitrobenzene
- Details on test material:
- - Test article: CGA 230672 techn.
- Purity test date: 97,3 %
- Lot/batch No.: P. 906005
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K Thomae GmbH, Chemisch-pharmazeutische Fabrik
- Age at study initiation: 9 - 13 weeks old
- Weight at study initiation: 2700 - 2880 g
- Housing: individually in metal cages
- Diet (e.g. ad libitum): yes (standart rabbit pellet, Nafag No. 814)
- Water (e.g. ad libitum): yes
- Acclimatisation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): ca. 20 °C
- Humidity (%): 30 - 70 %
- Photoperiod (hrs dark / hrs light): 12
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- skin reactions were evaluated 1, 24, 48 and 72 hours after removing the gauze patches.
The animals were checked daily for systemic symptoms and mortality. - Number of animals:
- 3 male rabbits
- Details on study design:
- TEST SITE
- Area of exposure: gauze patch (ca. 12-16 cm²) bearing 0,5 ml of the test article was applied to the right flank of each animal.
- coverage: the patches were loosely covered with an aluminium foil (ca. 36 cm²)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 - 72 hours
- Score:
- 0.33
- Max. score:
- 2
- Reversibility:
- fully reversible
- Remarks:
- until the end of the observation period on day 3
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 - 72 hours
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Remarks:
- until the end of the observation period on day 3
- Irritant / corrosive response data:
- non-irritant
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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