1,4-dichloro-2-(1,1,2,3,3,3-hexafluoropropoxy)-5-nitrobenzene

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1990

Report date:

1990

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

GLP compliance:

yes (incl. QA statement)

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

1,4-dichloro-2-(1,1,2,3,3,3-hexafluoropropoxy)-5-nitrobenzene

EC Number:

620-459-6

Cas Number:

130841-23-5

Molecular formula:

C9H3Cl2F6NO3

IUPAC Name:

1,4-dichloro-2-(1,1,2,3,3,3-hexafluoropropoxy)-5-nitrobenzene

Test animals

Species:

rat

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Ciba-Geigy Ltd., Animal Production
- Weight at study initiation: 166 - 211 g
- Housing: segregated by sex, group-housed (5 animals per cage) in Macrolon cages, type 4, with standardize soft wood bedding
- Diet (e.g. ad libitum): yes
- Water (e.g. ad libitum): yes
- Acclimation period: at least 5 days before exposure


ENVIRONMENTAL CONDITIONS
- Temperature (°C): ca. 22 °C
- Humidity (%): ca, 55 %
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12

Administration / exposure

Route of administration:

inhalation: aerosol

Type of inhalation exposure:

nose only

No. of animals per sex per dose:

5 per sex

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 5 360 mg/m³ air

Mortality:

No Mortalities occured upon exposure to CGA 230672 techn. at a conentration of 5366 mg/m3.
Consenquently, the study was considered a limit test as definded by the OECD test guideline 403.

Clinical signs:

other: In the animals exposed to the test article piloerection, huched posture, dyspnea, and reduced spontaneous activity were observed to a similar extend. They recovered within 9 days.

Body weight:

The mean body weight for the control group and the group exposed to the test article, measured before exposure and on days 7 and 14 for each sex, are shown in Table 3.
The test article exposed females showed a significant lower body weight grain in the second week after exposure.