Registration Dossier
Registration Dossier
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EC number: 620-459-6 | CAS number: 130841-23-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- 1,4-dichloro-2-(1,1,2,3,3,3-hexafluoropropoxy)-5-nitrobenzene
- EC Number:
- 620-459-6
- Cas Number:
- 130841-23-5
- Molecular formula:
- C9H3Cl2F6NO3
- IUPAC Name:
- 1,4-dichloro-2-(1,1,2,3,3,3-hexafluoropropoxy)-5-nitrobenzene
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 6 to 8 weeks
- Initial body weight range: 170 to 215 g
- Fasting period before study: fasted overnight
- Housing: housed in Macrolon cages type 4, with standardized soft wood bedding
- Diet (e.g. ad libitum): yes
- Water (e.g. ad libitum): yes
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): ca. 22°C
- Humidity (%): ca. 55%
- Air changes (per hr): ca. 15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Ol. arachidis Ph. H. VI
- Doses:
- Dose levels / sex group: - 1000 mg/kg, males and femals; - 2000 mg/kg, males and femals
- No. of animals per sex per dose:
- 5 per sex / per dose
20 animals total
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 - < 2 000 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 - < 2 000 mg/kg bw
- Mortality:
- daily; a.m. and p.m. on working days
a.m. on weekend days - Clinical signs:
- daily for 14 days
- Body weight:
- immediately before administration, on days 7, 14 and at death
- Gross pathology:
- Spontaneously dying animals were submitted to a gross necropsyas soon as possible; survivors at the and of the observation period
Applicant's summary and conclusion
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