Isopropyl 4-hydroxybenzoate

Toxicity to microorganisms

Link to relevant study record(s)

Reference

Endpoint:

toxicity to microorganisms, other

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Justification for type of information:

Data is from peer reviewed journal

Qualifier:

according to guideline

Guideline:

other: Refer below principle

Principles of method if other than guideline:

Bioluminescence inhibition of Vibrio fischeri was observed after different time duration from 5-15 min according to the V. fischeri acute toxicity test (Environmental Protection Series, 1992)

GLP compliance:

not specified

Specific details on test material used for the study:

- Name of test material (as cited in study report): Isopropylparaben
- Molecular formula: C10-H12-O3
- Molecular weight: 180.202 g/mol
- Smiles notation: c1(C(OC(C) C)=O)ccc(O)cc1
- InChl : 1S/C10H12O3/c17( 2)1310(12)8359(11)648/h37,11H,12H3
- Substance type: Organic
- Physical state: Solid

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

Vibrio fisheri

Test type:

not specified

Water media type:

freshwater

Total exposure duration:

15 min

Remarks on exposure duration:

5- 15 minute exposure duration

Reference substance (positive control):

not specified

Key result

Duration:

15 min

Dose descriptor:

EC50

Effect conc.:

0.62 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

test mat.

Basis for effect:

other: : Inhibition of Bioluminescence

Remarks on result:

other: Measured Conc.in the range 0.57–0.66 mg/l

Validity criteria fulfilled:

not specified

Conclusions:

According to the V. fischeri acute toxicity test (Environmental Protection Series, 1992) the EC50 value for isopropyl 4-hydroxybenzoate (4191-73-5) was observed to be 0.62 mg/l.

Executive summary:

Toxicity to microorganism was performed on V. fischeri by bioluminescence inhibition test. Luminescence was measured with a Microtox luminometer acute mode.Bioluminescence was measured after different time duration from 5- 15 min.Thus, from experiment it was concluded that the EC50 value for toxicity to Vibrio fischeri for isopropyl 4-hydroxybenzoate (4191-73-5) was observed to be 0.62mg/l.

Description of key information

According to the V. fischeri acute toxicity test (Environmental Protection Series, 1992) the EC50 value for isopropyl 4-hydroxybenzoate (4191-73-5) was observed to be 0.62 mg/l.

Key value for chemical safety assessment

EC50 for microorganisms:

0.62 mg/L

Additional information

Toxicity to microorganism was performed on V. fischeri by bioluminescence inhibition test. Luminescence was measured with a Microtox luminometer acute mode.Bioluminescence was measured after different time duration from 5- 15 min.Thus, from experiment it was concluded that the EC50 value for toxicity to Vibrio fischeri for isopropyl 4-hydroxybenzoate (4191-73-5) was observed to be 0.62mg/l.