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EC number: 224-069-3 | CAS number: 4191-73-5
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- Data is from peer reviewed journal
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- Bioluminescence inhibition of Vibrio fischeri was observed after different time duration from 5-15 min according to the V. fischeri acute toxicity test (Environmental Protection Series, 1992)
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Isopropylparaben
- Molecular formula: C10-H12-O3
- Molecular weight: 180.202 g/mol
- Smiles notation: c1(C(OC(C) C)=O)ccc(O)cc1
- InChl : 1S/C10H12O3/c17( 2)1310(12)8359(11)648/h37,11H,12H3
- Substance type: Organic
- Physical state: Solid - Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Vibrio fisheri
- Test type:
- not specified
- Water media type:
- freshwater
- Total exposure duration:
- 15 min
- Remarks on exposure duration:
- 5- 15 minute exposure duration
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 15 min
- Dose descriptor:
- EC50
- Effect conc.:
- 0.62 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- other: : Inhibition of Bioluminescence
- Remarks on result:
- other: Measured Conc.in the range 0.57–0.66 mg/l
- Validity criteria fulfilled:
- not specified
- Conclusions:
- According to the V. fischeri acute toxicity test (Environmental Protection Series, 1992) the EC50 value for isopropyl 4-hydroxybenzoate (4191-73-5) was observed to be 0.62 mg/l.
- Executive summary:
Toxicity to microorganism was performed on V. fischeri by bioluminescence inhibition test. Luminescence was measured with a Microtox luminometer acute mode.Bioluminescence was measured after different time duration from 5- 15 min.Thus, from experiment it was concluded that the EC50 value for toxicity to Vibrio fischeri for isopropyl 4-hydroxybenzoate (4191-73-5) was observed to be 0.62mg/l.
Reference
Description of key information
According to the V. fischeri acute toxicity test (Environmental Protection Series, 1992) the EC50 value for isopropyl 4-hydroxybenzoate (4191-73-5) was observed to be 0.62 mg/l.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 0.62 mg/L
Additional information
Toxicity to microorganism was performed on V. fischeri by bioluminescence inhibition test. Luminescence was measured with a Microtox luminometer acute mode.Bioluminescence was measured after different time duration from 5- 15 min.Thus, from experiment it was concluded that the EC50 value for toxicity to Vibrio fischeri for isopropyl 4-hydroxybenzoate (4191-73-5) was observed to be 0.62mg/l.
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