Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 224-069-3 | CAS number: 4191-73-5
Endpoint summary
Administrative data
Description of key information
Biodegradation in water
28-days Closed Bottle test following the OECD guideline 301 D to determine the ready biodegradability of the test item. The study was performed at a temperature of 20°C. The test system included control, test item and reference item. Polyseed were used as inoculum at concentration 10E7 to 10E8 CFU/ml. The concentration of test and reference item (Sodium Benzoate) chosen for both the study was 4 mg/L, while that of inoculum was 32 ml. The % degradation of procedure control (reference item) was also calculated using BOD & ThOD and was determined to be 76.5 %. Degradation of Sodium Benzoate exceeds 45.18% on 7 days & 70.48% on 14th day. The activity of the inoculum was thus verified and the test can be considered as valid. The BOD28 value of Isopropyl 4-hydroxybenzoate(CAS No.4191-73-5) was observed to be 1.25 mgO2/mg. ThOD was determined by calculation as 2.04 mgO2/mg. Accordingly, the % degradation of the test item after 28 days of incubation at 20 ± 1°C according to Closed Bottle Test was found to be 61.27%. Based on the results, the test item, under the test conditions, was considered to be readily biodegradable in nature.
Biodegradation in water and sediment
Estimation Programs Interface (EPI) Suite (2017) prediction model was run to predict the half-life in water and sediment for the test compound
Isopropyl 4-hydroxybenzoate (CAS No. 4191 -73 -5). If released in to the environment, 18.8% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of Isopropyl 4-hydroxybenzoate in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of
Isopropyl 4-hydroxybenzoate in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical Isopropyl 4-hydroxybenzoate into the sediment is less than 1% (i.e, reported as 0.206%), indicates that Isopropyl 4-hydroxybenzoate is not persistent in sediment.
Biodegradation in soil
The half-life period of Isopropyl 4-hydroxybenzoate (CAS No.4191-73-5) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 80.9% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of Isopropyl 4-hydroxybenzoate in soil is estimated to be 30 days (720 hrs). Based on this half-life value of Isopropyl 4-hydroxybenzoate , it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
Additional information
Biodegradation in water
28-days Closed Bottle test following the OECD guideline 301 D to determine the ready biodegradability of the test item. The study was performed at a temperature of 20°C. The test system included control, test item and reference item. Polyseed were used as inoculum at concentration 10E7 to 10E8 CFU/ml. The concentration of test and reference item (Sodium Benzoate) chosen for both the study was 4 mg/L, while that of inoculum was 32 ml. The % degradation of procedure control (reference item) was also calculated using BOD & ThOD and was determined to be 76.5 %. Degradation of Sodium Benzoate exceeds 45.18% on 7 days & 70.48% on 14th day. The activity of the inoculum was thus verified and the test can be considered as valid. The BOD28 value of Isopropyl 4-hydroxybenzoate(CAS No.4191-73-5) was observed to be 1.25 mgO2/mg. ThOD was determined by calculation as 2.04 mgO2/mg. Accordingly, the % degradation of the test item after 28 days of incubation at 20 ± 1°C according to Closed Bottle Test was found to be 61.27%. Based on the results, the test item, under the test conditions, was considered to be readily biodegradable in nature.
Biodegradation in water and sediment
Estimation Programs Interface (EPI) Suite (2017) prediction model was run to predict the half-life in water and sediment for the test compound
Isopropyl 4-hydroxybenzoate (CAS No. 4191 -73 -5). If released in to the environment, 18.8% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of Isopropyl 4-hydroxybenzoate in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of
Isopropyl 4-hydroxybenzoate in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical Isopropyl 4-hydroxybenzoate into the sediment is less than 1% (i.e, reported as 0.206%), indicates that Isopropyl 4-hydroxybenzoate is not persistent in sediment.
Biodegradation in soil
The half-life period of Isopropyl 4-hydroxybenzoate (CAS No.4191-73-5) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 80.9% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of Isopropyl 4-hydroxybenzoate in soil is estimated to be 30 days (720 hrs). Based on this half-life value of Isopropyl 4-hydroxybenzoate , it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
On the basis of available information, the test substance Isopropyl 4 -hydroxybenzoate can be considered to be readily biodegradable in nature.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
