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EC number: 224-069-3 | CAS number: 4191-73-5
Endpoint summary
Administrative data
Description of key information
Appearance:
Based on available data from peer reviewed publication, the chemical isopropyl 4 -hydroxybenzoate observed to be Colourless crystal or white crystalline powder in appearance having no odour.
Melting point:
The melting point determination of Test chemical was done as per the test guideline OECD 102. The method followed was according to Capillary/metal block. The Mean melting temperature range was determined to be 82.1- 85.8°C at 967.8hPa.
Boiling point:
The boiling point determination of Isopropyl 4-hydroxybenzoate (CAS No. 4191-73-5) was done following OECD Guideline 103 and according to the method of Siwoloboff and boiling point was determine to be greater than 270 °C at 966.9 hPa.
Density:
The density of test item Isopropyl 4-hydroxybenzoate (CAS No. 4191-73-5)was determined following OECD Guideline 109 and according to the method adapted from ASTM D 854-02 using glass pyknometer The mean density of test item was determine to be 1.2081 g/cm³ at 20°C and 968.05 hPa.
Particle size (granulometry):
The particle size distribution of test item Isopropyl 4-hydroxybenzoate (CAS No. 4191-73-5 ) was determined by granulometric analysis with rotap sieve shaker. The particle size distribution was determine to be in 150 micron.
Vapor Pressure:
Data from authoritative databases suggests that the estimated vapor pressure ofisopropyl paraben at 25 deg C was 0.155Pa.
Partition coefficient:
The partition Coefficient n-octanol/water of Isopropyl 4-hydroxybenzoate (CAS No.4191-73-5) was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals.The reference substances were chosen according to functional similarity with the test substance and calibration graph was prepared. The reference substances were having Pow value ranging from 1.3 to 4.6 The Log Pow value was determine to be 2.316 ± 0.000 at 25°C. This value indicates that the substance is hydrophilic in nature.
Water solubility:
The water solubility determination of test item Isopropyl 4-hydroxybenzoate (CAS No. 4191-73-5) was done as per the OECD guideline 105 by spectrophotometric analytical method as per OECD 101. The solubility of (Isopropyl 4-hydroxybenzoate of CAS No. 4191-73-5) in water was determine to be 1204.1 mg/L at 25°C. Thus test chemical is considered to be soluble in water.
Surface tension:
Based on the data from ACD labs, surface tension for isopropyl 4-hydroxybenzoate was predicted to be 41.5 ± 3.0 dyne/cm.
Flash point:
The flash point determination of Isopropyl 4-hydroxybenzoate (CAS No. 4191-73-5) was done following closed cup method using Pensky-Martens flash point apparatus. The test was conducted in replicates and mean flash point was found to be 123°C at 967.3hPa.
Autoflammability:
Isopropyl 4-hydroxybenzoate did not catch fire on being exposed to air at room temperature of 27°Cpressure of 966 hPa. This indicates that isopropyl 4-hydroxybenzoate is not auto-flammable.
Flammability:
Isopropyl 4-hydroxybenzoatedoes not indicate any ignition when the flame of bunsen burner having temperature of approximately 950°C is brought in contact with it. Thus it can be concluded thatIsopropyl 4-hydroxybenzoateis not flammable at high temperature. However since such high temperatures are not found under normal circumstances of transportation and use, thusIsopropyl 4-hydroxybenzoate
was considered non-flammable for chemical safety assessment.
Explosiveness:
The study does not need to be conducted because there are no chemical groups present in the molecule which are associated with explosive properties
Oxidising properties:
The study does not need to be conducted because there are no chemical groups present in the molecule which are associated with oxidising properties and hence, the classification procedure does not need to be applied
Viscosity:
The study does not need to be conducted because the substance is a solid
pH:
The pH determination of test item Isopropyl 4-hydroxybenzoate (CAS No. 4191-73-5 ) was done as per the test guideline OECD 122. The mean pH of the test dispersionwas determined with the help of digital pH meter. The mean pH was found to be 4.63 at 26 °C
Additional information
Appearance:
Based on available data from peer reviewed publication, the chemical isopropyl 4-hydroxybenzoate observed to be Colourless crystal or white crystalline powder in appearance having no odour.
Other supporting studies from safety data sheet indictates that the chemical isopropyl 4-hydroxybenzoate observed to be an organic solid in appearance.
Melting point:
Various studies were summarized for the determination of melting point:
The melting point determination of Test chemical was done as per the test guideline OECD 102. The method followed was according to Capillary/metal block. The Mean melting temperature range was determined to be 82.1- 85.8°C at 967.8hPa.
Based on available data from peer viewed publication, the melting point of chemical isopropyl 4-hydroxybenzoatewas determined to be in the range of 97 degree C to 99 degree C.
Based on available data from authoritative database, the melting point of chemical isopropyl 4-hydroxybenzoate was determined to be 86 degree C.
Boiling point:
The boiling point determination of Isopropyl 4-hydroxybenzoate (CAS No. 4191-73-5) was done following OECD Guideline 103 and according to the method of Siwoloboff and boiling point was determine to be greater than 270 °C at 966.9 hPa.
Based on available data from authoritative database, the boiling point of chemical isopropyl 4-hydroxybenzoate was determined to be in the range of 158 degree C to 160 degree C at 5 torr pressure.
Thus based on the first experimental key study boiling point was consider to be greater than 270 °C at 966.9 hPa.
Density:
The density of test item Isopropyl 4-hydroxybenzoate (CAS No. 4191-73-5)was determined following OECD Guideline 109 and according to the method adapted from ASTM D 854-02 using glass pyknometer The mean density of test item was determine to be 1.2081 g/cm³ at 20°C and 968.05 hPa.
Particle size (granulometry):
The particle size distribution of test item Isopropyl 4-hydroxybenzoate (CAS No. 4191-73-5 ) was determined by granulometric analysis with rotap sieve shaker. The particle size distribution was determine to be in 150 micron.
Vapor Pressure:
Data from authoritative databases suggests that the estimated vapor pressure ofisopropyl paraben at 25 deg C was 0.155Pa.
Partition coefficient:
The partition Coefficient n-octanol/water of Isopropyl 4-hydroxybenzoate (CAS No.4191-73-5) was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals.The reference substances were chosen according to functional similarity with the test substance and calibration graph was prepared. The reference substances were having Pow value ranging from 1.3 to 4.6 The Log Pow value was determine to be 2.316 ± 0.000 at 25°C. This value indicates that the substance is hydrophilic in nature.
Data from various authoritative databases and peer reviewed journals suggests that the estimated octanol water partition coefficient (log Pow) of isopropyl paraben was 2.91.
Water solubility:
The water solubility determination of test item Isopropyl 4-hydroxybenzoate (CAS No. 4191-73-5) was done as per the OECD guideline 105 by spectrophotometric analytical method as per OECD 101. The solubility of (Isopropyl 4-hydroxybenzoate of CAS No. 4191-73-5) in water was determine to be 1204.1 mg/L at 25°C. Thus test chemical is considered to be soluble in water.
Surface tension:
Based on the data from ACD labs, surface tension for isopropyl 4-hydroxybenzoate was predicted to be 41.5 ± 3.0 dyne/cm.
Flash point:
The flash point determination of Isopropyl 4-hydroxybenzoate (CAS No. 4191-73-5) was done following closed cup method using Pensky-Martens flash point apparatus. The test was conducted in replicates and mean flash point was found to be 123°C at 967.3hPa.
Autoflammability:
Isopropyl 4-hydroxybenzoate did not catch fire on being exposed to air at room temperature of 27°Cpressure of 966 hPa. This indicates that isopropyl 4-hydroxybenzoate is not auto-flammable.
Flammability:
Isopropyl 4-hydroxybenzoatedoes not indicate any ignition when the flame of bunsen burner having temperature of approximately 950°C is brought in contact with it. Thus it can be concluded thatIsopropyl 4-hydroxybenzoateis not flammable at high temperature. However since such high temperatures are not found under normal circumstances of transportation and use, thusIsopropyl 4-hydroxybenzoate
was considered non-flammable for chemical safety assessment.
Explosiveness:
The study does not need to be conducted because there are no chemical groups present in the molecule which are associated with explosive properties
Oxidising properties:
The study does not need to be conducted because there are no chemical groups present in the molecule which are associated with oxidising properties and hence, the classification procedure does not need to be applied.
pH:
The pH determination of test item Isopropyl 4-hydroxybenzoate (CAS No. 4191-73-5 ) was done as per the test guideline OECD 122. The mean pH of the test dispersionwas determined with the help of digital pH meter. The mean pH was found to be 4.63 at 26 °C
Viscosity:
The study does not need to be conducted because the substance is a solid
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