Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-147-5 | CAS number: 78-82-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted pre-GLP and pre-guideline, so details in the report are lacking. However, the study was conducted at a highly reputable laboratory, and was done to the state of the art at the time.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 960
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The study was conducted prior to OECD guidelines, but it follows the general layout of OECD 405.
- GLP compliance:
- no
Test material
- Reference substance name:
- Butyronitrile
- EC Number:
- 203-700-6
- EC Name:
- Butyronitrile
- Cas Number:
- 109-74-0
- Molecular formula:
- C4H7N
- IUPAC Name:
- butanenitrile
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- None given
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 1 drop
- Duration of treatment / exposure:
- 14 days
- Observation period (in vivo):
- 14 days
- Number of animals or in vitro replicates:
- 1
- Details on study design:
- One drop of test article was applied to the eyes of a single rabbit followed by a 14-day observation period
Results and discussion
In vivo
Results
- Irritation parameter:
- other:
- Time point:
- other: 24 hours
- Score:
- > 0 - < 0
- Reversibility:
- not specified
- Remarks on result:
- other: No score was given but as TCC demands a value, dummy numbers were used.
- Irritant / corrosive response data:
- Eyes were held closed briefly. Slight erythema of conjunctiva. Normal at 1 hr and 24 hours, although there was slight staining of nictitating membrane with fluorescein. Normal at 14 days.
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The test article was minimally irritating.
- Executive summary:
The test article was minimally irritating.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
