Registration Dossier
Registration Dossier
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EC number: 221-346-0 | CAS number: 3072-84-2
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 29/01/2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Principles of method if other than guideline:
- BCF estimation is performed by the BCF base-line model v.02.05. The model evaluates the maximum bioconcentration potential (log BCFmax) of chemicals based on their lipophilicity and further applies mitigating factors that can reduce the calculated maximum value.
- GLP compliance:
- no
- Key result
- Value:
- 32 dimensionless
- Calculation basis:
- other: QSAR model
- Remarks on result:
- not measured/tested
- Conclusions:
- Component A F-2200
Component A is characterized by high lipophilicity. Although its log Kow value (log Kow=5.74) would classify it as bioaccumulative, mitigating factors are taken into consideration which reduced its maximum bioaccumulation potential. The BCF base-line model estimates that size and metabolism as most significant mitigating factors reducing its bioaccumulation down to log BCF = 1.51 leading to ultimate classification as Not bioaccumulative.
The results are confirmed by observed data for structural analogues identified in the Toolbox (also in training set of the BCF base-line model). - Executive summary:
Component A F-2200
Component A is characterized by high lipophilicity. Although its log Kow value (log Kow=5.74) would classify it as bioaccumulative, mitigating factors are taken into consideration which reduced its maximum bioaccumulation potential. The BCF base-line model estimates that size and metabolism as most significant mitigating factors reducing its bioaccumulation down to log BCF = 1.51 leading to ultimate classification as Not bioaccumulative.
The results are confirmed by observed data for structural analogues identified in the Toolbox (also in training set of the BCF base-line model).
Reference
Description of key information
Component A F-2200
Component A is characterized by high lipophilicity. Although its log Kow value (log Kow=5.74) would classify it as bioaccumulative, mitigating factors are taken into consideration which reduced its maximum bioaccumulation potential. The BCF base-line model estimates that size and metabolism as most significant mitigating factors reducing its bioaccumulation down to log BCF = 1.51 leading to ultimate classification as Not bioaccumulative.
The results are confirmed by observed data for structural analogues identified in the Toolbox (also in training set of the BCF base-line model).
Key value for chemical safety assessment
- BCF (aquatic species):
- 32 dimensionless
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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