4-cyanophenyl acetate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2005

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP study according EU/OECD guideline

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2005

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

GLP compliance:

yes (incl. QA statement)

Test type:

acute toxic class method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

4-cyanophenyl acetate

EC Number:

235-893-8

EC Name:

4-cyanophenyl acetate

Cas Number:

13031-41-9

Molecular formula:

C9H7NO2

IUPAC Name:

4-cyanophenyl acetate

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

DMSO

Doses:

300 / 2000 mg/kg bw

No. of animals per sex per dose:

6 animals at 300 mg/kg
3 animals at 2000 mg/kg bw

Control animals:

no

Results and discussion

Effect levels

Effect levels 1

Sex:

female

Dose descriptor:

LD50

Effect level:

>= 300 - <= 2 000 mg/kg bw

Remarks on result:

other: no CL given

Effect levels 2

Sex:

female

Dose descriptor:

LD50

Effect level:

ca. 500 mg/kg bw

Based on:

test mat.

Applicant's summary and conclusion

Interpretation of results:

harmful

Remarks:

Migrated information Criteria used for interpretation of results: EU

Executive summary:

The test material was classified as HARMFUL and the symbol “Xn” and risk phrase R 22 “HARMFUL IF SWALLOWED” are required according to EU labelling regulations Commission Directive 2001/59/EC for classification and labelling of dangerous substances.