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Physical & Chemical properties

Water solubility

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water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
according to guideline
OECD Guideline 105 (Water Solubility)
GLP compliance:
yes (incl. QA statement)
Type of method:
column elution method
Specific details on test material used for the study:
Identification: 2-Propenoic acid, 2 [[(octadecylamino)carbonyl]oxy]ethyl ester
Appearance/Physical state: White solid
Purity: >98%
Storage conditions: Room temperature in the dark
Key result
Water solubility:
< 0 g/L
Conc. based on:
test mat.
20 °C
>= 6 - <= 7.1
Details on results:
As the water solubility was determined during the preliminary test to be below 10-2 g/L and the test item was a solid, the column elution method was performed.

The peak area of the samples was approximately the lowest standard and close to the limit of detection, some integrated peaks were considered integrated noise and therefore the overall test result was taken as a limit value based on the standard of lowest concentration (0.01 mg/L) used in the linearity which was analyzed during the same analytical sequence with the concentration factor (0.025) applied, providing a limit value of 2.5 x 10-7 g/L.

The method of analysis showed some variability likely due to the low working level. Due to this, not all of the samples fell within ± 30% of the mean as specified in the test guidelines. There was however no obvious issues with the chromatography (e.g. contamination) which would account for the variability, and therefore all of the sample results were included in the overall result. The variability was also reduced by the use of the limit value, therefore with the use of the limit value samples are then within ± 30%.
The water solubility of the test item has been determined to be less than 2.5 x 10-7 g/L of solution at 20.0 ± 0.5 °C.

Description of key information

In an OECD 105 study, under GLP conditions, the water solubility of 2-Propenoic acid, 2[[(octadecylamino)carbonyl]oxy]ethyl ester is less than 2.5 x 10-7g/L of solution at 20.0 ± 0.5 °C (Envigo, 2016a).

Key value for chemical safety assessment

Water solubility:
0 mg/L
at the temperature of:
20 °C

Additional information