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EC number: 203-427-2 | CAS number: 106-72-9
Endpoint summary
Administrative data
Description of key information
LD50s >5000 mg/kg for both oral and dermal studies.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- March 1974
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 10 animals were dosed with 5gm/kg of test substance and observed for 14 days
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 10 animals total
- Control animals:
- no
- Details on study design:
- Standard oral LD50 protocol at the time.
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- no deaths were seen in the 14 day observation period.
- Clinical signs:
- None
- Body weight:
- NA
- Gross pathology:
- NA
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No toxicity was observed in the study at the limit of 5000 mg/kg bw
- Executive summary:
10 animals were dosed with 5gm/kg of test substance and observed for 14 days. No toxicity was observed in the study at the limit of 5000 mg/kg bw.
Reference
Distribution of Mortality
| Observation Day | ||||||||||||||
| Route | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 |
| Oral | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- March 1974
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 4 animals were dosed at 5 mg/kg bodyweight and observed for 14 days
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- no data
- Doses:
- 5 mg/kg
- No. of animals per sex per dose:
- 4 animals total
- Control animals:
- no
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- No deaths were seen during the 14 day observation period
- Clinical signs:
- Mild erythema on rabbits lasting 24 hours.
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- No toxicity was seen in the 4 animals during the 14 day observation period.
- Executive summary:
In the study, 4 animals were dosed at 5 mg/kg bodyweight and observed for 14 days. No toxicity was seen in the 4 animals during the 14 day observation period.
Reference
Distribution of Mortality
| Observation Day | ||||||||||||||
| Route | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 |
| Dermal | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mild erythema on rabbits lasting 24 hours.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Additional information
Oral
An acute oral toxicity test was carried out on groups of young adult rats at dose levels of 5 gms/kg bodyweight. No deaths and no overt signs of toxicity were observed during the fourteen day observation periods. No toxicity was observed in the study at the limit of 5 gms/kg bw. The LD50 was therefore greater than 5 gms/kg bodyweight.
Dermal
In the study, 4 animals were dosed at 5 mg/kg bodyweight and observed for 14 days. No toxicity was seen in the 4 animals during the 14 day observation period.
Symptomatology: Mild erythema on rabbits lasting 24 hours. No toxicity was observed in the study at the limit of 5 gms/kg bw. The LD50 was therefore greater than 5 gms/kg bodyweight.
Justification for classification or non-classification
No effects seen in either oral or dermal studies. Substance considered not classified for toxic effects.
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