Registration Dossier
Registration Dossier
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EC number: 405-370-0 | CAS number: 6334-25-4
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: SNIF file in pdf format received from ECHA
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- -
- EC Number:
- 405-370-0
- EC Name:
- -
- Cas Number:
- 6334-25-4
- Molecular formula:
- C14H28N2O6
- IUPAC Name:
- N,N,N',N'-tetrakis(2-hydroxyethyl)hexanediamide
- Test material form:
- solid: particulate/powder
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: Salmonella typhimurium strains TA 98, TA 100, TA 1535, TA 1537 and TA 1538
- Metabolic activation:
- not specified
- Metabolic activation system:
- Aroclor-induced rat liver s)
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation):0...5000 µg/plate
Concentration range in the main test (without metabolic activation):0...5000 µg/plate - Vehicle / solvent:
- Solvetn: Water
Results and discussion
Test resultsopen allclose all
- Species / strain:
- other: as specified above
- Metabolic activation:
- with
- Genotoxicity:
- not specified
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- > 5000 µg/plate
- Species / strain:
- other: as specified above
- Metabolic activation:
- without
- Genotoxicity:
- not specified
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- > 5000 µg/plate
- Species / strain:
- other: as specified above
- Metabolic activation:
- with
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- > 5000 u/g/plate
- Species / strain:
- other: as specified above
- Metabolic activation:
- without
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- > 5000 u/g/plate
- Additional information on results:
- Observations:
No toxicity was observed - Remarks on result:
- other: other: preliminary test
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
We are not in the position to fill all the fields. The data supplied as annex to ECHA Letter dated April 28, 2011 does not show other data than the one inserted here. ECHA letter "Communication relating to your inquiry under regulation (EC) no 1907/2006" ( Submission number WZ219074-00)
Applicant's summary and conclusion
- Conclusions:
- negative with metabolic activation
negative without metabolic activation - Executive summary:
Note: All info and data in this end point / section is according to ECHA data as annex of inquiry no 06 -0000021150 -88 -0000
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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