Registration Dossier
Registration Dossier
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EC number: 405-370-0 | CAS number: 6334-25-4
Endpoint summary
Administrative data
Description of key information
N,N,N',N'-tetrakis-(2-hydroxyethyl) hexanediamide is of very low oral and dermal acute toxicity with an oral LD50 (rat) of > 5000 mg/kg bw (Lampe' and Baldwin, 1988) and a dermal LD50 (rabbit) of > 5000 mg/kg bw (Lampe' and Baldwin, 1988).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Additional information
In the test for acute and dermal toxicity, the test compound
was applied to rats and rabbits at single doses of 5,000 mg/kg body
weight. There were no mortalities or body weight effects in
any of the studies. Diarrhea, observed 4 hours after oral
administration, was the only treatment related clinical
sign. Necropsy revealed no gross changes.
Justification for classification or non-classification
Based on the results of the acute oral and dermal studies and according to the criteria of EC Regulation 1272/2008 N,N,N',N'-tetrakis-(2-hydroxyethyl) hexanediamide has a very low acute toxicity if swallowed or if comes into contact with skin. Therefore, the test item must not be classified.
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