Registration Dossier
Registration Dossier
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EC number: 202-809-6 | CAS number: 100-00-5
Immunotoxicity
Administrative data
- Endpoint:
- immunotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given
Data source
Reference
- Title:
- No information
- Author:
- Li Q, Minami M, Hanaoka T, Yamamura Y (1999) Acute|immunotoxicity of p-chloronitrobenzene in mice: II. Effect|of p-chloronitrobenzene on the immunophenotype of murine|splenocytes determined by flow cytometry. Toxicology 137:|35-45 (1999)
Materials and methods
- Principles of method if other than guideline:
- other: see remark
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1-chloro-4-nitrobenzene
- EC Number:
- 202-809-6
- EC Name:
- 1-chloro-4-nitrobenzene
- Cas Number:
- 100-00-5
- Molecular formula:
- C6H4ClNO2
- IUPAC Name:
- 1-chloro-4-nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): 1-chloro-4-nitrobenzene
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: BDF1
- Sex:
- male
Administration / exposure
- Route of administration:
- other: i.p. or s.c.
- Vehicle:
- other: olive oil
- Frequency of treatment:
- once
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 300 mg/kg bw
Basis:
- No. of animals per sex per dose:
- 24
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Type: other
Observation period: up to 10 days
Results and discussion
Any other information on results incl. tables
Spleen weight sign. greater in exposed animals
Indication of immunotoxic effect: Reduction of natural
killer cells, T cells and B cells in the spleen, and
increase in macrophages and nucleated erythrocythes and dead
cells (after i.p.) in the spleen
comparison of i.p. and s.c. application: sign. difference in
macrophages and nucleated erythrocytes, i.p. more
macrophages, s.c. more nucleated erythrocytes
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
