Registration Dossier
Registration Dossier
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EC number: 936-882-7 | CAS number: 1352319-02-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according EU/OECD guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- (2001)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 1-(3-chloropyridin-2-yl)-3-{[5-(trifluoromethyl)-2H-1,2,3,4-tetrazol-2-yl]methyl}-1H-pyrazole-5-carboxylic acid
- EC Number:
- 936-882-7
- Cas Number:
- 1352319-02-8
- Molecular formula:
- C12H7ClF3N7O2
- IUPAC Name:
- 1-(3-chloropyridin-2-yl)-3-{[5-(trifluoromethyl)-2H-1,2,3,4-tetrazol-2-yl]methyl}-1H-pyrazole-5-carboxylic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: polyethylene glycol 400
- Doses:
- 2000 mg/kg body weight (bw)
- No. of animals per sex per dose:
- six female rats
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Remarks on result:
- other: No mortalities occurred at a dose level of 2000 mg/kg bw, therefore, a LD50 >5000 mg/kg bw was derived according to OECD TG 423
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- A dose of 2000 mg/kg body weight was tolerated by female rats without mortalities, clinical signs, effects on weight development and gross pathological findings. The test material is non-toxic after acute oral administration at the dose level of 2000 mg/kg bw. Since no mortalities occurred at a dose level of 2000 mg/kg bw, a LD50 >5000 mg/kg bw was derived according to OECD TG 423.
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