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EC number: 200-888-1 | CAS number: 75-64-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- tert-butylamine
- EC Number:
- 200-888-1
- EC Name:
- tert-butylamine
- Cas Number:
- 75-64-9
- Molecular formula:
- C4H11N
- IUPAC Name:
- 2-methylpropan-2-amine
- Details on test material:
- - Name of test material (as cited in study report): tert.-butylamine, substance no. 84/396
- Analytical purity: 98%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomae GmbH, Biberach, Germany
- Fasting period before study: 16 hours
- Housing: groups of 5 in stainless steel wire mesh cages type DK-III
- Diet: Kliba laboratory diet, Klingenthalermuehle AG, Kaiseraugst, Switzerland ad libitum
- Water: tap water ad libitum
- Acclimation period: at least 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 3.61, 4.64, 6.81 (w/v), respectively
- Justification for choice of vehicle: Aqueous formulation corresponds to the physiological medium
MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg - Doses:
- 316, 464, 681 mg/kg bw
- No. of animals per sex per dose:
- 5 males, 5 females per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: several times daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 316 - < 464 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 514 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 464 mg/kg bw
- Mortality:
- 681 mg/kg dosing group: 5/5 females, 4/5 males (d 1-d 14)
464 mg/kg dosing group: 1/5 females, 5/5 males (d 1-d 14)
316 mg/kg dosing group: no death occurred - Clinical signs:
- other: dyspnoea, apathy, staggering, tremors, piloerection, diarrhea, salivation, stretching, imbalance, poor general condition
- Gross pathology:
- mid and high dosing groups:
haemorrhagic gastritis, bloody content of intestine, acute peritonitis, local adhesions of stomach and liver, single animals with acute serous peritonitis as a result of perforation of the stomach, single animals with very severe tymanitas, one animal with perforated duodenal ulcer, swollen margo plicatus (cuticular ridge)
lowest dosing group:
1 male with acute lung emphysema and haemorrhagic intestinal content, other animals without findings
Applicant's summary and conclusion
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