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EC number: 406-176-9 | CAS number: 79072-96-1 NC-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.4500 (Acute Eye Irritation)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,6-bis(4-ethylphenyl)perhydro-1,3,5,7-tetraoxanaphth-4-ylethane-1,2-diol
- EC Number:
- 406-176-9
- EC Name:
- 2,6-bis(4-ethylphenyl)perhydro-1,3,5,7-tetraoxanaphth-4-ylethane-1,2-diol
- Cas Number:
- 79072-96-1
- Molecular formula:
- C24 H30 O6
- IUPAC Name:
- 1-[2,6-bis(4-ethylphenyl)-hexahydro-[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 30 mg - Duration of treatment / exposure:
- Single application
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- 6 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: no effects at any time poiint
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- 6 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects at any time point
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Remarks:
- 4 animals
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 24 hrs
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Remarks:
- 2 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other: no effects at any time point
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- 1 animals
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 hrs
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- 5 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects at any time point
- Irritant / corrosive response data:
- No adverse effects were observed for the iris or corneal damage at any time point in any animal.
Minor conjuncitval irritation (redness) was observed in 4 animals and resolved within 1 day.
Minor chemosis was observed in 1 animals and resolved within 1 day.
Any other information on results incl. tables
Endpoint |
Mean score |
Maximum value |
Maximum duration of any effect |
Maximum value at the end of observation period |
Conjunctivae / redness |
1 in 4 animals 0 in 2 animals |
1 in 4 animals |
1 day |
0 |
Chemosis |
1 in 1 animal 0 in 5 animals |
1 in 1 animal |
1 day |
0 |
Cornea |
0 |
0 |
- |
0 |
Iris |
0 |
0 |
- |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No adverse effects were observed for the iris or corneal damage at any time point in any animal.
Minor conjuncitval irritation (redness) was observed in 4 animals and minor chemosis was observed in 1 animal. All eyes were normal after 1 day.
A single application of test material into the rabbit eye did not produce a positive response according to CLP criteria.
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