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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
in vivo mammalian germ cell study: gene mutation
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No OECD or GLP defined.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1985

Materials and methods

Principles of method if other than guideline:
Method: other: no data
GLP compliance:
not specified
Type of assay:
Drosophila SLRL assay

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-dichloro-4-nitrobenzene
EC Number:
210-248-3
EC Name:
1,3-dichloro-4-nitrobenzene
Cas Number:
611-06-3
Molecular formula:
C6H3Cl2NO2
IUPAC Name:
1,3-dichloro-4-nitrobenzene
Details on test material:
IUCLID4 Test substance: no data

Test animals

Species:
Drosophila melanogaster
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: feed
Duration of treatment / exposure:
3 d
Frequency of treatment:
no data
Post exposure period:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
20, 30 ppm (feeding); 60 ppm (injection)
Basis:

No. of animals per sex per dose:
no data
Control animals:
not specified

Examinations

Tissues and cell types examined:
Sex-linked recessive lethal (SLRL) assay

Results and discussion

Test results
Sex:
not specified
Genotoxicity:
negative

Any other information on results incl. tables

RS-Freetext:
Negativ

      Lethals
 Compound  Feeding  Injection
 2,4 -Dichloronitrobenzene  -  -

Applicant's summary and conclusion

Executive summary:

In a feeding and injection Drosophila mutagenicity test the test substance was judged to be nonmutagenic.