Registration Dossier
Registration Dossier
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EC number: 210-248-3 | CAS number: 611-06-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study and GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,3-dichloro-4-nitrobenzene
- EC Number:
- 210-248-3
- EC Name:
- 1,3-dichloro-4-nitrobenzene
- Cas Number:
- 611-06-3
- Molecular formula:
- C6H3Cl2NO2
- IUPAC Name:
- 1,3-dichloro-4-nitrobenzene
- Test material form:
- other: solid
- Details on test material:
- IUCLID4 Test substance: other TS
TS-Freetext:
Reinheit: >99.5 %
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- physiological saline
- Controls:
- not specified
- Amount / concentration applied:
- 500 mg/animal
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 72 h
- Number of animals:
- 3
- Details on study design:
- With physiological saline moistened test substance was applied to the shaved skin and fixed with a plaster. After the 4 h exposure time the treatment area was rinsed with water observed for 72 hours and evaluated according to Draize
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not irritating
- Remarks on result:
- other: not irritating
- Irritant / corrosive response data:
- the substance is evaluated to be non-irritating
- Other effects:
- -
Any other information on results incl. tables
Results:
| Time after patch removal | 30 -60 min. | 24 h | 48 h | 72 h | ||||||||
| Animal No: | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 |
| Formation of erythema and eschar | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Formation of edema | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Applicant's summary and conclusion
- Executive summary:
In a skin irritation/corrosion study in rabbits according to OECD TG 404 and GLP the animals were treated with 500 mg of test substance moistened with 0.18 ml isotonic saline for 4 hours. 30 -60 minutes after patch removal in all animals a very slight erythem could be observed. After 24 hours after patch removal in all animals no irritation symptoms could be observed any more.
The test substance was evaluated to be not irritating according to directive 83/467/EWG.
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