Registration Dossier
Registration Dossier
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EC number: 257-269-4 | CAS number: 51548-48-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: data from safety assessment reports
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- 7-Amino-4-hydroxy-2-naphthalenesulfonic acid
- Author:
- BG Chemie
- Year:
- 2 000
- Bibliographic source:
- BG Chemie InfoCenter, TOXIKOLOGISCHE BEWERTUNGEN; TOXICOLOGICAL EVALUATION last updated: 06/2000
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the eye irritation potential of the test substance using Standard Draize test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 7-amino-4-hydroxynaphthalene-2-sulphonic acid
- EC Number:
- 201-718-9
- EC Name:
- 7-amino-4-hydroxynaphthalene-2-sulphonic acid
- Cas Number:
- 87-02-5
- IUPAC Name:
- 7-amino-4-hydroxynaphthalene-2-sulfonic acid
- Reference substance name:
- 7-Amino-4-hydroxy-2-naphthalenesulfonic acid
- IUPAC Name:
- 7-Amino-4-hydroxy-2-naphthalenesulfonic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Name of test material (as cited in study report): 7-Amino-4-hydroxy-2-naphthalenesulfonic acid
Molecular formula: C10H9NO4S
Molecular weight: 239.25g/mol
Substance type: organic
Physical state: solid
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 24 hours
- Number of animals or in vitro replicates:
- no data
- Details on study design:
- area of exposure: conjunctival sac
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24
- Remarks on result:
- other: mild irritation was observed after 24 hours
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
In a eye irritation study, approx. 500 mg 7-amino-4-hydroxy-2-naphthalenesulfonic acid (I acid) was instilled into the eyes of the rabbits.
Mild eye irritation was observed after 24 hours
Hence the test chemical can be considered non-irritant to rabbit eyes.- Executive summary:
In an eye irritation study in rabbits, 50 mg 7-amino-4-hydroxy-2-naphthalenesulfonic acid (I acid) was instilled into the conjunctival sac of 2 animals
New Zealand white rabbits were used for the study.
The animals were observed for 24 hours
Mild eye irritation was observed after 24 hours.
Hence the test chemical can be considered non-irritant to rabbit eyes
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