Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Bioaccumulation: aquatic / sediment

Based on the predicted data by BCFBAF Program (v3.01) model the Bioaccumulation factor (BCF) was predicted to be 11.46 L/kg wet-wt at 25 deg.C. Based on the BCF concentration it is concluded that the test chemical p-tolyl acetate is non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.

Additional information

Bioaccumulation: aquatic / sediment

By applying weight of evidence approach to Bioaccumulation potential for the target chemical p-tolyl acetate (Cas no. 140-39-6) and its read across chemical which is 60-70 % structurally similar to target were reviewed to summarize as follows:  

First study from prediction model EPI suite 2017 using BCFBAF Program (v3.01) model the Bioaccumulation factor (BCF) was predicted to be 11.46 L/kg wet-wt at 25 deg.C.

Similarly another prediction model PBT profiler; 2017 indicated that the Bioaccumulation factor (BCF) was predicted to be 11 L/kg wet-wt at 25 deg.C for target p-tolyl acetate.

One another predicted database i.e Scifinder; 2017 for target substance indicate the Bioconcentration factor (BCF) was predicted to be 22.4 at pH 1-10 and temperature 25 deg.C.

Information from Chemspider - ACD/PhysChem Suite prediction model, for the Bioconcentration factor (BCF) for target chemical p-tolyl acetate was predicted to be 25.47 at pH 5.5 and 7.4 and temperature 25 deg.C.

Whereas data from HSDB database; 2017 for read across chemical Phenyl acetate (Cas no. 122-79-2) indicate an estimated BCF of 8 was calculated for phenyl acetate, using a log Kow value of 1.49 and a regression-derived equation. This BCF suggests the potential for bioconcentration in aquatic organisms is low.

Thus based on the above all studies it is concluded that the test substance chemical p-tolyl acetate (Cas no. 140-39-6) is non Bioaccumulative in aquatic environment.