Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 270-648-9 | CAS number: 68475-50-3
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
By QSAR Toolbox version 3.3 predicted model the toxicity to micro organism (IGC50) in Tetrahymena pyriformis was estimated to be 122.513618469 mg/l for 48 hrs in static condition and in fresh water for test substance Tris(5-amino-4-hydroxy-3-(phenylazo)naphthalene-2,7-disulphonato(2-))dialuminium with Growth inhibition effect.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 122.514 mg/L
Additional information
Toxicity to micro organism was assessed for the target compound Tris(5-amino-4-hydroxy-3-(phenylazo)naphthalene-2,7-disulphonato(2-))dialuminium (CAS no 68475-50-3) and its related read- across. The summary of the results are presented below:
Toxic effects of the test compound Tris(5-amino-4-hydroxy-3-(phenylazo)naphthalene-2,7-disulphonato(2-))dialuminium (CAS no 68475-50-3) was predicted (SSS QSAR, 2016). The study was based on the effects of the test compound on the micro organism species Tetrahymena pyriformis in 48 hrs duration in a fresh water static system. The predicted data suggests the Inhibition growth concentration (IGC50) on the basis of growth inhibition to be 122.513618469 mg/L. This value concluded that the test compound Tris(5-amino-4-hydroxy-3-(phenylazo)naphthalene-2,7-disulphonato(2-))dialuminium does not exhibit toxicity to micro organism (Tetrahymena pyriformis) and is non hazardous to the aquatic environment.
Whereas experimental study (Chemophere. Vol. 28, No. 12, pp. 2203.2236, 1994) for read across substance 2-aminonaphthalene-1-sulphonic acid (Cas no. 81-16-3)indicate that the effect concentrations i.e EC50 of test substance for bacteria (unadapted biological waste water treatment plant) was found to be >10000 mg/l.
Same experimental source i.e Chemophere. Vol. 28, No. 12, pp. 2203.2236, 1994 also report the the study for another read across 6-amino 1,3-naphthalene-disulfonic acid (Cas no. 118-33-2)which indicate that the effect concentration (EC50) of test substance 6 amino-1,3 naphthalene –disulfonic acid for bacteria (unadapted biological waste water treatment plant) was found to be 1000 mg/l for 24 hrs. on the basis of inhibition effect.
Based on above available studies for target chemical and its relevant read across it is concluded that the substance Tris(5-amino-4-hydroxy-3-(phenylazo)naphthalene-2,7-disulphonato(2-))dialuminium (CAS no 68475-50-3) non toxic to micro organisms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
