Registration Dossier
Registration Dossier
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EC number: 203-851-8 | CAS number: 111-26-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from RTECS database
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Acute oral toxicty of CAS no 111-26-2
- Author:
- RTECS
- Year:
- 2 001
- Bibliographic source:
- EPA TSCA Section 8(b) CHEMICAL INVENTORY DATA BASE, JANUARY 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: asbelow
- Principles of method if other than guideline:
- Acute oral toxicity study of hexylamine in rabbit
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- Hexylamine
- EC Number:
- 203-851-8
- EC Name:
- Hexylamine
- Cas Number:
- 111-26-2
- Molecular formula:
- C6H15N
- IUPAC Name:
- hexan-1-amine
- Test material form:
- other: Liquid
- Details on test material:
- - Name of test material (as cited in study report): n- hexylamine
- Molecular formula (if other than submission substance): C6H15N
- Molecular weight (if other than submission substance): 101.191 g/mole
- Substance type: organic
- Physical state: Liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Type of coverage:
- other: Dermal
- Vehicle:
- not specified
- Details on dermal exposure:
- No data available
- Duration of exposure:
- No data available
- Doses:
- No data available
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 318.48 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- No data available
- Clinical signs:
- No data available
- Body weight:
- No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 was considered to be 318.48 mg/k bw when rabbits were treated with Hexylamine by dermal application.
- Executive summary:
In a acute dermal toxicity study, rabbits were treated with Hexylamine by dermal application. 50 % mortality observed in treated rabbits at 318.48 mg/k bw . Therefore, LD50 was considered to be 318.48 mg/k bw when rabbits were treated with Hexylamine by dermal application.
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