Trisodium 1-amino-4-[[3-[[4-chloro-6-[(3-sulphonatophenyl)amino]-1,3,5-triazin-2-yl]amino]-2,4,6-trimethyl-5-sulphonatophenyl]amino]-9,10-dihydro-9,10-dioxoanthracene-2-sulphonate

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2014

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

Principles of method if other than guideline:

None

GLP compliance:

no

Type of method:

flask method

Water solubility:

332 g/L

Temp.:

20 °C

Remarks on result:

other: pH is not known

Details on results:

None

None

Conclusions:

Interpretation of results (migrated information): very soluble (> 10000 mg/L)
The water solubility cs of the test item at a temperature of 20 °C was determined to (without correction for the purity): cs = 332 g/l

Executive summary:

This study was conducted according to OECD guideline 105 .

The water solubility cs of the test item at a temperature of 20 °C was determined to (without correction for the purity): cs = 332 g/l

Reference 2

Endpoint:

water solubility

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Justification for type of information:

REPORTING FORMAT FOR THE ANALOGUE APPROACH

1. HYPOTHESIS FOR THE ANALOGUE APPROACH
This read-across is based on the hypothesis that the source and the target substance have very similar physicochemical and (eco)toxicological properties because their chemical structures are nearly identical. An analogue approach has thus been employed. The target substance is the meta-isomer of the dye Reactive Blue 049, where the sulphonate group is bound at the meta-position of the aminobenzene moiety. The source chemical is the reaction mass of both the meta-isomer and the para-isomer of Reactive Blue 049.
The presence of sulphonate groups make both dyes highly water soluble and therefore less critical for human health and environmental issues. Based on their chemical similarity, similar properties are expected in both humans and the environment.

2. SOURCE AND TARGET CHEMICAL(S)
Source: Reactive Blue 49 meta/para (CAS# 72214-18-7 / EC# 276-481-8)
Target: Reactive Blue 49 meta (CAS# 72927-99-2 / EC# 277-040-2)

3. ANALOGUE APPROACH JUSTIFICATION
see attachment under 4.2 Melting point / freezing point

Reason / purpose for cross-reference:

read-across source

Key result

Water solubility:

332 g/L

Conc. based on:

test mat.

Temp.:

20 °C

Remarks on result:

other: pH is not reported

Details on results:

None

None

Conclusions:

The water solubility of the test item at a temperature of 20 °C was determined to be 332 g/L

Executive summary:

This study was conducted according to OECD guideline 105 .

The water solubility cs of the test item at a temperature of 20 °C was determined to (without correction for the purity): cs = 332 g/L

Description of key information

The water solubility at a temperature of 20 °C was determined to be 332 g/L

Key value for chemical safety assessment

Water solubility:

332 g/L

at the temperature of:

20 °C

Additional information

This study was conducted according to OECD guideline 105. The water solubility of the source substance at a temperature of 20 °C was determined (without correction for the purity) to be 332 g/L. The structurally related target substance will have a similar very high solubility in water.