Registration Dossier
Registration Dossier
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EC number: 261-693-5 | CAS number: 59312-61-7
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other: Assessment based on physicochemical properties and toxicological data
- Adequacy of study:
- supporting study
- Study period:
- 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- other: Expert judgment
- Title:
- Unnamed
- Year:
- 2 017
Materials and methods
- Objective of study:
- absorption
- distribution
- excretion
- metabolism
- toxicokinetics
- Principles of method if other than guideline:
- Assessment based on physicochemical properties and toxicological data
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,2-dihydro-6-hydroxy-1,4-dimethyl-2-oxo-5-[[3-[(phenylsulphonyl)oxy]phenyl]azo]nicotinonitrile
- EC Number:
- 261-693-5
- EC Name:
- 1,2-dihydro-6-hydroxy-1,4-dimethyl-2-oxo-5-[[3-[(phenylsulphonyl)oxy]phenyl]azo]nicotinonitrile
- Cas Number:
- 59312-61-7
- Molecular formula:
- C20H16N4O5S
- IUPAC Name:
- 3-[(5-cyano-2-hydroxy-1,4-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)diazenyl]phenyl benzenesulfonate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Disperse Yellow 114 would be absorbed primarily in gastrointestinal tract, while limited absorption via dermal and inhalation exposure can be expected at high doses. Systemic distribution would most likely occur along the gastrointestinal tract. Predominant route of excretion is expected to be through faeces, however, it may get metabolized to a more hydrophilic product and may also get excreted via urine at high doses.
- Executive summary:
Disperse Yellow 114 would be absorbed primarily in gastrointestinal tract, while limited absorption via dermal and inhalation exposure can be expected at high doses. Systemic distribution would most likely occur along the gastrointestinal tract. Predominant route of excretion is expected to be through faeces, however, it may get metabolized to a more hydrophilic product and may also get excreted via urine at high doses.
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