Registration Dossier
Registration Dossier
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EC number: 203-540-7 | CAS number: 107-99-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Gene mutation of the target 2-Chloro-N,N-dimethylethan-1-amine was estimated by using the following predictors: Derek Nexus, Sarah Nexus, Vega (four models). The predictors were employed in order to apply a weight of evidence (WoE) approach to enhance the reliability of the prediction. In the weight of evidence assessment only reliable predictions are to be taken into account. The target compound has been found in the training set of three Vega models with a mutagenic experimental value (CAESAR, SarPy/IRFMN, KNN/Read-Across). Vega ISS model predicted the target compound as mutagenic (moderate reliable).
Derek Nexus predicted Chromosome damage in vitro, Chromosome damage in vivo and Mutagenicity in vitro as PLAUSIBLE. Sarah Nexus predicted the target compound as positive with 100% confidence. Therefore, it was concluded that 2-Chloro-N,N-dimethylethan-1-amine was predicted with a high level of confidence as positive.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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