1-(4-trans-Pentylcyclohexyl)-4-propylbenzene

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

23.10.-06.11.1984

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: This study was performed according to GLP and the methods applied are fully compliant with OECD TG 401.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1985

Report date:

1985

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

1-(4-trans-Pentylcyclohexyl)-4-propylbenzene

EC Number:

617-422-1

Cas Number:

82991-48-8

Molecular formula:

C₂₀H₃₂

IUPAC Name:

1-(4-trans-Pentylcyclohexyl)-4-propylbenzene

Test material form:

other: liquid

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS- Source: E. Merck, Darmstadt- Age at study initiation: young- Weight at study initiation: 161 (152 - 171) g - Fasting period before study: 17 hours before until up to 4 hours after treatment- Housing: separately in type III Makrolon cages - Diet (e.g. ad libitum): ad libitum- Water (e.g. ad libitum): ad libitum- Acclimation period: 7 days ENVIRONMENTAL CONDITIONS- Temperature (°C): 17 to 26 °C - Humidity (%): 36 to 45 %- Photoperiod (hrs dark / hrs light): 12 hour light - 12 hour dark regimeIN-LIFE DATES: From: day 1 To: day 15

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: Methocel KM4 Premium

Details on oral exposure:

Test materialVolume of administrationDose levelin g/100 mLml/100 gmg/kg----------------------------------------------------10550005control

Doses:

5000 mg/kg bwcontrol

No. of animals per sex per dose:

test group: 10: 5 (m) / 5 (f)control group: 10: 5 (m) / 5 (f)

Control animals:

yes

Details on study design:

- Duration of observation period following administration: 15 days- Frequency of observations and weighing: on days 2, 4, 6, 8, 11, 13, and 15 of the experimental part.- Necropsy of survivors performed: yes- Other examinations performed: clinical signs, body weight, gross pathology

Statistics:

Standard statistical methods have been applied for data processing.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

One female rat died on the second day. All other animals survived the observation periond up to day 15.

Clinical signs:

No signs of toxicity were seen after treatment.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated informationCriteria used for interpretation of results: EU

Conclusions:

Based on the result of this study, it is concluded that the test material has no acute toxic potential and that the LD50 value is higher than 5000 mg/kg bw after single oral administration in rats.

Executive summary:

Study design

In this study, the acute toxicity of the test material in rats after single oral administration of 5000 mg/kg body weight was investigated. The study was performed according to the OECD Guideline for Testing of Chemicals, No. 401.

Results

No signs of toxicity were seen in the rats (5 males, 5 females) after treatment with the test item. One female rat died on the second day. All other animals survived the observation periond up to day 15.
There was a small difference in body weight gain between treated and control group on the second day of the study. Otherwise the body weight development of the rats was inconspicuous during the study.
The female rat died on day 2 had changes in the gaster, locally blood content in the small intestine and a moderate hydrometra. No findings have been recorded for the rats killed after the observation period (day 15).

Conclusion

Based on the result of this study, it is concluded that the test material has no acute toxic potential and that the LD₅₀value is higher than 5000 mg/kg bw after single oral administration in rats.