Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Endpoint summary
Administrative data
Description of key information
Based on the available repeated dose study NOAEL is set at 500 mg/kg bw/day for findings representing local toxicity consisted of inflammatory/hyperplastic lesions in the large intestines at 1000 and 2000 mg/kg along with presumed secondary white blood cell changes.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 500 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Additional information
Justification for classification or non-classification
Based on the available repeated dose study NOAEL is set at 500 mg/kg bw/day for increased kidney weights observed in male animals at the low dose. Based on these effects and the NOAEL classification and labelling is not warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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