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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

No experimental study is availlable on the substance to evaluate the irritation potential.
Skin irritation was predicted by the software Tox Boxes 2.9; eye irritation was predicted by DEREK analysis.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation / corrosion
Remarks:
other: In silico prediction.
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
June, 2010
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6
Qualifier:
no guideline followed
Principles of method if other than guideline:
Skin irritation module estimates the potential of a compound to cause skin irritation in a standard rabbit Draize test.
Tox Boxes 2.9 is the in house software for the prediction of basic toxicity endpoints in chemicals. Predictions are made analyzing the chemical structure and based upon large validated databases and QSAR models, in combination with expert knowledge of organic chemistry and toxicology.
GLP compliance:
not specified
Species:
rabbit
Strain:
not specified
Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Number of animals:
No animals used.
Remarks on result:
other: Skin irritation shows an alert with an high predicted value.
Interpretation of results:
other: alert
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
Skin irritation shows an alert with an high predicted value. Generally, the piperazine derivatives in most cases exhibit rabbit skin irritating properties.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation
Remarks:
other: in silico prediction
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
June, 2010
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6
Qualifier:
no guideline followed
Principles of method if other than guideline:
In silico prediction using DEREK.
GLP compliance:
not specified
Remarks on result:
other: DEREK evaluation showed no alert for eye irritation
Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
Derek evaluation for the test item showed no alerts.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Skin irritation shows an alert with an high predicted value. Generally, the piperazine derivatives in most cases exhibit rabbit skin irritating properties.

Derek evaluation for the test item showed no alerts for ocular irritation; no reliability is declared.

The substance 1-(3-chlorophenyl)-4-(3-chloropropyl)piperazinium chloride is classified as skin irritant. Irritation to the eyes could be reasonable expected.


Justification for selection of skin irritation / corrosion endpoint:
Only study available

Justification for selection of eye irritation endpoint:
Only study available

Effects on skin irritation/corrosion: irritating

Justification for classification or non-classification

The substance 1-(3-chlorophenyl)-4-(3-chloropropyl)piperazinium chloride is classified as skin irritant category 2 and eye irritant category 2.