Registration Dossier
Registration Dossier
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EC number: 258-038-0 | CAS number: 52605-52-4
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
- Objective of study:
- other: HERG channel inhibition
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1-(3-chlorophenyl)-4-(3-chloropropyl)piperazinium chloride
- EC Number:
- 258-038-0
- EC Name:
- 1-(3-chlorophenyl)-4-(3-chloropropyl)piperazinium chloride
- Cas Number:
- 52605-52-4
- Molecular formula:
- C13H18Cl2N2.ClH
- IUPAC Name:
- 1-(3-chlorophenyl)-4-(3-chloropropyl)piperazin-1-ium chloride
Constituent 1
Results and discussion
Any other information on results incl. tables
Derek evaluation for the test item showed alerts for HERG channel inhibition.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: alert
Derek evaluation for the test item showed alerts for HERG channel inhibition. - Executive summary:
This alert describes a structure based pharmacophore developed primarily from compounds that have been reported to be strong inhibitors of the HERG (human ether-a-go-go-related gene) potassium channel.
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